Κατεύθυνση Επεμβατική Καρδιολογία
Library of the School of Health Sciences

2019-06-20

2019

Papanikolaou Paraskevi

Τούσουλης Δημήτριος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κυρίτση Ελένη, Ομότιμη Καθηγήτρια, Τμήμα Νοσηλευτικής, ΤΕΙ Αθήνας
Τούτουζας Κωνσταντίνος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Σχέση της ποσότητας σπλαχνικού και υποδόριου κοιλιακού λίπους με την έκταση της περιφερικής αθηρωμάτωσης

Greek

Correlation between the amount of visceral and subcutaneous adipose tissue and the extend of atherosclerotic burden in peripheral artery

Introduction: Peripheral artery disease (PAD) is a usually underdiagnosed disease. Atherosclerosis has a pivotal role in the pathogenesis of PAD. It is known that inflammation and endothelial dysfunction are involved in atherosclerosis. Adipose tissue is no longer considered a passive storage tissue, but an active endocrine organ responsible for the secretion of an amount of hormones defining the cardio metabolic profile. Current research data suggest the complicated physiology of the different types of adipose tissue and their influence on vascular inflammation and atherosclerosis.
Purpose: In this study, we investigated the correlation of the amount of visceral and subcutaneous adipose tissue with extend of atherosclerosis of peripheral arteries.
Materials/methods: We analyzed retrospectively the images of CT scans of 99 patients hospitalized in Hippokrateion hospital the time period between January 2015 and January 2017. We used specific protocol to quantify the amount of visceral and subcutaneous adipose tissue. We checked the presence of abdominal aorta aneurysm (AAA). Finally, we measured the extent of atherosclerosis of peripheral arteries applying the Agatston score to measure aortoiliac calcification.
Results: The amount of visceral adipose tissue was positively correlated to the extent of peripheral atherosclerosis (r=0.557, p=<0.001), whereas the amount of subcutaneous adipose tissue was negatively correlated to peripheral atherosclerosis with no statistical significance (r=-.129, p=0.204). More correlations to the age and sex have been done. There was no statistical significant correlation between the age and the amount of visceral adipose tissue and the value of aortoiliac atherosclerotic calcification. Moreover, the male gender was correlated to greater amount of visceral adipose tissue (p=0.026) and increased aortoiliac calcification (r= 0.289, p=0.004). Moreover, we noticed that the aortoiliac calcium burden was increased in the groups of patients with PAD and AAA compared to controls. In these different groups of patients, we didn’t reveal a statistically significant correlation to the amount of visceral and subcutaneous adipose tissue. Finally, we have to mention that the ratio of visceral to subcutaneous adipose tissue was increased in patients with higher values of aortoiliac calcium burden.
Conclusion: In this study, we showed that the amount of visceral adipose tissue was correlated to aortoiliac calcium burden. These results are in accordance to current research data that adipose tissue has a complex role to atherosclerosis and vascular disease. CT imaging can be very useful to quantify adipose tissue and the degree of atherosclerosis. More researches should take place in order to better understand the new imaging markers. According to them, risk stratification methods would be improved in order to identify the patients group in greater cardiometabolic risk.
 

Health Sciences

Adipose tissue, Cardiometabolic risk, Peripheral atheroma, Subcutaneous adipose tissue, Visceral adipose tissue, Atherosclerosis, Computed Tomography

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https://pergamos.lib.uoa.gr/uoa/dl/object/2876389