Department of Nursing
Library of the School of Health Sciences

2019-07-08

2019

Giamaiou Konstantina

Τσουμάκας Κωνσταντίνος, Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ, Επιβλέπων
Παυλοπούλου Ιωάννα, Αναπληρώτρια Καθηγήτρια, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Ελευσινιώτης Ιωάννης, Αναπληρωτής Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Φιλντίσης Γεώργιος, Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Μαντάς Ιωάννης, Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Καλοκαιρινού Αθηνά, Καθηγήτρια, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Φώτος Νικόλαος, Επίκουρος Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ

Ιογενείς λοιμώξεις σε παιδιά που υποβάλλονται σε μεταμόσχευση αρχέγονων αιμοποιητικών κυττάρων

Greek

Viral infections among children undergoing hematopoietic stem cell transplant

Background: Viral infections are a significant cause of morbidity and mortality in pediatric transplant populations. We analyzed the epidemiology of viral infections in pediatric hematopoietic stem cell transplant (HSCT) patients, including their incidence, associated risk factors, and outcome. Methods: In a prospective study all patients who underwent HSCT from September 2011 to September 2015 were participated. Blood, urine and stool specimens were monitored weekly from transplantation to day 100 or after if clinically suspected, by use of real-time polymerase chain reaction. Cytomegalovirus (CMV), Epstein-Barr virus (EBV), BK polyomavirus (BKV), Herpes simplex virus - 1, 2, Varicella zoster virus, Human herpes virus - 6, 7, and Adenovirus infections were monitored. All children and adolescents who underwent HSCT received long term follow up in the regular outpatient clinics (range 2-48 months). Results: A total of 192 HSCTs (autologous/allogeneic: 53/139) were performed in 165 subjects (median age: 5, 6 yrs). Viruses most commonly isolated were CMV (46,1%), BKV (25,9%) and EBV (22,6%) and were more frequent in allogeneic versus autologous transplants (p<0,05). Almost all high risk allogeneic recipients developed EBV infections post HSCT. EBV-PTLD was the only cause of death among those who developed viral disease. The factors significantly associated with the development of viral infections were recipient's advanced age, unrelated donor, mismatched graft and use of peripheral blood stem cells grafts. Conclusions: Viral infections were common among our pediatric recipients. Data suggest that monitoring of viral load may be significant to the prevention of viral disease.Particular demographic and transplantation characteristics were associated with the development of viral infections post-HSCT.

Health Sciences

Viral infections, Hematopoietic stem cell transplant, Risk factors, Children

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https://pergamos.lib.uoa.gr/uoa/dl/object/2878025