Unit:
Κατεύθυνση Κλινικοπαθολογοανατομική θεώρηση των νεοπλασιών του ανθρώπουLibrary of the School of Health Sciences
Author:
Bala Vanessa-Meletia
Supervisors info:
Σ. Θεοχάρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Π. Κορκολοπούλου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Χ. Γακιοπούλου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Υποδοχείς κανναβινοειδών στον καρκίνο του νεφρού
Translated title:
Cannabinoid receptors in renal cell carcinoma
Summary:
Kidney cancer, a common urologic malignancy with major limitations in therapy, is among the 10 most frequently occurring cancers worldwide. Cannabinoids are the primary components of cannabis and exhibit diverse effects in various disorders in humans, including psycotropic actions as well as preventing neoplasticity. They act through binding in receptors called cannabinoid receptors, G-protein coupled receptors (GPCRs) and participate in many signal transducing pathways. Recent literature has suggested that CBR1 and CBR2 play key roles in the pathogenesis of many cancer types, including gliomas, breast cancer, prostate cancer, pancreatic cancer and various haematological malignancies. Latest updates about the aberrant localisation and gene expression of cannabinoid receptors in different cell types of kidney, underline a potential contribution that promotes renal cancer pathogenesis. In this review, we tried to enlighten that Cannabinoids may be emerging as potential diagnostic and prognostic markers and/or as therapeutic targets in specific types of malignancy, offering a promising research area for the development of novel biomarkers in solid tumors, such as RCC.
Main subject category:
Health Sciences
Keywords:
Cannabinoid receptors, Renal cell carcinoma, Endocannabinoid system
Number of references:
197
File:
File access is restricted only to the intranet of UoA.
Bala Vanessa Master.pdf
2 MB
File access is restricted only to the intranet of UoA.
