Κατεύθυνση Βιοπληροφορική
Library of the School of Science

2019-11-03

2019

Kadda Anna

Αλέξανδρος Γεωργακίλας, Αναπληρωτής Καθηγητής, Τομέας Φυσικής, Σχολή Εφαρμοσμένων Μαθηματικών και Φυσικών Επιστημών, Εθνικό Μετσόβιο Πολυτεχνείο
Χατζηιωάννου Αριστοτέλης, Ερευνητής, Ινστιτούτο Βιολογίας, Εθνικό Ίδρυμα Ερευνών
Βοργιάς Κωνσταντίνος, Καθηγητής, Τμήματος Βιολογίας, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών

Ανάλυση βιολογικών επιδράσεων και θεραπευτικών ιδιοτήτων της κουρκουμίνης (curcumin) μέσω ανάλυσης μικροσυστοιχιών RNA και μετανάλυσης

Greek

Analysis of the biological effects and therapeutic properties of curcumin by RNA microarray analysis and meta-analysis

Curcuma is a spice derived from the curcuma or turmeric plant (scientifically called Curcuma longa). It is mainly used in Asian cuisine, as well as in dyeing textiles or food. The main active ingredient of turmeric is curcumin, which has been associated with antioxidant and anti-inflammatory properties, as well as exerting anti-cancer effects on a variety of biological pathologies involved in metastasis, oncogenesis and apoptosis. It is also believed to help in the prevention and treatment of diseases (such as Alzheimer's disease and various degenerative diseases) associated with inflammation and oxidative stress.
Our aim is to examine the response of hepatocellular carcinoma cells to curcumin. More specifically we studied:
• If the hepatocellular cancer lines respond to curcumin
• If the hepatocellular cancer lines respond in a common way to curcumin,
• Which biological mechanisms hepatocellular cancer lines respond to curcumin,
• How the metabolic response of sensitive hepatocellular cancer lines differs with the metabolic response of resistant hepatocellular cancer lines in the presence of curcumin,
• If these mechanisms can explain why they appear sensitive or resistant to the environment in the presence of curcumin.
Microarrays data were analyzed using the R programming language as well as bioconductor bioinformatics packages and libraries. In addition to the functional analysis, bioinformatics tools were used to obtain results concerning biological functions of curcumin response phenomena.
The results revealed already known mechanisms from the literature and different responses of liver cell lines in the presence of curcumin.

Science

microarrays, gene expression analysis, curcumin, hepatocellular cancer lines, functional analysis

Yes

3

Yes

112

104

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https://pergamos.lib.uoa.gr/uoa/dl/object/2884667