Unit:
Κατεύθυνση Αναπαραγωγική-Αναγεννητική Ιατρική
Library of the School of Health Sciences
Library of the School of Health Sciences
Deposit date:
2019-12-09
Year:
2019
Author:
Mastrodima-Polychroniou Sofia
Supervisors info:
Δρακάκης Πέτρος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Ντόμαλη Αικατερίνη, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Μαυρογιάννη Δέσποινα, ΕΔΙΠ, Ιατρική Σχολή, ΕΚΠΑ
Ντόμαλη Αικατερίνη, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Μαυρογιάννη Δέσποινα, ΕΔΙΠ, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Ιντερλευκίνες και αυτόματες αποβολές
Languages:
Greek
Translated title:
Interleukins and recurrent miscarriages
Summary:
Automatic miscarriages or abortion is one of the most common complications of pregnancy and occurs in 10-15% of women. According to the World Health Organization, automatic miscarriage is considered to be a fetal loss <500 grams. with <20 weeks of gestational age. About 0.5-2% of women suffer from miscarriages or recurrent miscarriages, defined as three or more failed clinically diagnosed pregnancies. Despite significant advances in the field of gynecology and in vitro fertilization science, their etiology is still unclear nowadays.
As is well known, the immune response and particularly the production of cytokines, varies from person to person. This is partly due to the genetic polymorphism of their gene expression.
According to the latest data, fetal survival cytokines, are predominantly Th2 (IL-4, IL-10, IL-13) and Th3 (TGF-1β), whereas pregnancy failure with the prevalence of Th1 type cytokines (IL-2, TNF-α, IL-12), or Th17 (IL-17). Therefore, knowing that for specific cytokines, there are specific functional polymorphisms, it has been suggested that women with sudden miscarriages may be characterized by a genetic predisposition of 'cytotoxin-type Th1 overexpression'.
The purpose of this diploma thesis is to quote both the already known data that compose the scene of automatic miscarriages and the latest results of experimental studies.
These are mainly related to how much harmful or not is the existence or loss of certain interleukins during pregnancy, also with the phenomena of genomic polymorphisms of certain Th1 and Th2 interleukins, which most often adversely affects the smooth outcome of a pregnancy, by presenting IL-35, as an interleukin essential to maintaining pregnancy and finally to establish as a basic prerequisite for maintaining a pregnancy not only the already known Th1
As is well known, the immune response and particularly the production of cytokines, varies from person to person. This is partly due to the genetic polymorphism of their gene expression.
According to the latest data, fetal survival cytokines, are predominantly Th2 (IL-4, IL-10, IL-13) and Th3 (TGF-1β), whereas pregnancy failure with the prevalence of Th1 type cytokines (IL-2, TNF-α, IL-12), or Th17 (IL-17). Therefore, knowing that for specific cytokines, there are specific functional polymorphisms, it has been suggested that women with sudden miscarriages may be characterized by a genetic predisposition of 'cytotoxin-type Th1 overexpression'.
The purpose of this diploma thesis is to quote both the already known data that compose the scene of automatic miscarriages and the latest results of experimental studies.
These are mainly related to how much harmful or not is the existence or loss of certain interleukins during pregnancy, also with the phenomena of genomic polymorphisms of certain Th1 and Th2 interleukins, which most often adversely affects the smooth outcome of a pregnancy, by presenting IL-35, as an interleukin essential to maintaining pregnancy and finally to establish as a basic prerequisite for maintaining a pregnancy not only the already known Th1
Main subject category:
Health Sciences
Keywords:
Interleukins, Recurrent miscarriages
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
180
Number of pages:
91
Persistent URL:
