Unit:
Τομέας ΠαθολογίαςLibrary of the School of Health Sciences
Author:
Prevezas Christos
Dissertation committee:
Σφηκάκης Πέτρος, Καθηγητής, Ιατρική, ΕΚΠΑ
Ρηγόπουλος Δημήτριος , Καθηγητής, Ιατρική, ΕΚΠΑ
Στρατηγός Αλέξανδρος , Καθηγητής, Ιατρική, ΕΚΠΑ
Βασιλόπουλος Δημήτριος , Καθηγητής, Ιατρικής, ΕΚΠΑ
Κατούλης Αλέξανδρος , Αναπλ. Καθηγητής ,Ιατρική, ΕΚΠΑ
Ευαγγελία Παπαδαυίδ, Αναπλ. Καθηγήτρια ,Ιατρική, ΕΚΠΑ
Νικολαΐδου Ηλέκτρα , Αναπλ. Καθηγήτρια, Ιατρική, ΕΚΠΑ
Original Title:
Συγκριτική μελέτη των δεικτών pasi napsi και dlqi σε ασθενείς με ψωριασική ονυχία
Translated title:
Correlational study of pasi napsi and dlqi indexes in patients with nail psoriasis
Summary:
Background: Response to treatment in patients suffering from skin and nail psoriasis is quantitatively evaluated by monitoring clinical severity and quality of life indexes, especially in the context of clinical trials. Among them, PASI, NAPSI and DLQI are currently the indexes most widely used.
Objective: To study the short-term correlation between PASI, NAPSI and DLQI in patients with skin and nail psoriasis, at baseline and at 3 months after treatment initiation.
Materials and Methods: This was a two-center prospective, observational, cross-sectional study of 40 treatment-naive patients, suffering from chronic plaque psoriasis with nail involvement, and requiring systemic therapy. Disease activity and quality of life were assessed at baseline and at 3 months after treatment initiation by measuring PASI, NAPSI and DLQI scores. Statistical correlations between theses indexes were investigated using the appropriate statistical tests.
Results: A positive, strong correlation was observed between DLQI and NAPSI at baseline (r=0.579, p <0.001) and at 3 months (r=0.484, p=0.002). Similarly, a strong correlation was noted between DLQI and PASI at baseline (r=0.496, p=0.001) and at 3 months (r=0.401, p=0.01). Moreover, we observed a positive strong correlation (r = 0.515, p=0.001) between DLQI at baseline and NAPSI at 3 months, and a moderate correlation (r = 0.433, p=0.005) between DLQI at baseline and PASI at 3 months.
Conclusion: The observed positive correlations between PASI, NAPSI, and DLQI, provide further evidence in support of their simultaneous utilization in clinical studies for skin and nail psoriasis. Moreover, the predictive value of DLQI at baseline emphasizes the importance of quality of life assessment, when designing a therapeutic study, as well as in the everyday clinical practice.
Main subject category:
Health Sciences
Keywords:
Chronic plaque psoriasis, Nail psoriasis, Clinical severity index, Quality of life, Statistical correlation, Treatment
Number of references:
156
