Unit:
Κατεύθυνση Θρόμβωση-Αιμορραγία-Ιατρική των μεταγγίσεωνLibrary of the School of Health Sciences
Supervisors info:
Σερένα Βαλσάμη, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, Ε.Κ.Π.Α., Επιβλέπουσα
Στυλιανή Κοκόρη, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, Ε.Κ.Π.Α.
Σοφία Βασιλοπούλου, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, Ε.Κ.Π.Α.
Original Title:
Ενδείξεις αντιαιμοπεταλιακών και αντιπηκτικών στα ισχαιμικά αγγειακά εγκεφαλικά επεισόδια
Translated title:
Indications of antiplatelets and anticongulants in ischemic strokes
Summary:
Ischemic stroke is one of the most important causes of death and disability in the world. Preventing the recurrence of an ischemic attack is important. Secondary prevention of ischemic strokes includes modification of risk factors and appropriate antithrombotic therapy. Antithrombotic therapy includes antiplatelet and anticoagulation therapy, and aims at the cause of ischemic infarct. The purpose of laboratory, imaging and invasive control presented by a patient with ischemic stroke is to find the cause and thus to take appropriate antithrombotic therapy. In a sample of 50 patients who were hospitalized in the General Hospital of Nikaia with ischemic stroke or transient ischemic attack, age, gender, risk factors, history of old stroke or transient ischemic attack, TOAST classification and secondary prophylactic antithrombotic treatment were recorded. The purpose of the study was to record the incidence of risk factors and the TOAST categories in patients younger than 65 years old, as well as the antithrombotic treatment they received based on the cause and the patient's profile. The minimum diagnostic control required by the TOAST categories through electrocardiogram, brain imaging and control of extracranial and intracranial blood vessels was performed in all patients. Individual cardiac tests were performed with a heart ultrasound, a holter of 24 hours, and control of thrombophilia. The risk factors and the TOAST categories were recorded, as well as their effect on all patients, of both sexes and different age groups. The incidence of stroke relapse was also studied, as well as the antithrombotic treatment that patients received for secondary relapse prophylaxis and its associated relationship with TOAST categories. In conclusion, smoking, dyslipidemia and hypertension are the most frequent risk factors. Heart failure and coronary artery disease have significantly greater incidence in men with stroke or transient ischemic attack. The disease of large and small blood vessels is the most common cause of ischemic stroke not only in all patients but also in ages >55 years, while in ages ≤ 45 cryptogenic infarctions are more frequent. The incidence of cardiogenic infracts exhibits a statistically significant difference in women, and is a frequent cause in age ≤ 45 years. The most frequently administered prophylactic antithrombotic therapy is antiplatelet and the most frequent antiplatelet is aspirin. A 10% suffered a relapse of stroke or transient ischemic attack while these patients were already in antithrombotic treatment. Relapse occurs more often in men with statistically significant difference. This is significant and shows the importance of choosing correct antithrombotic therapy for secondary prophylaxis of ischemic strokes.
Main subject category:
Health Sciences
Keywords:
Ischemic, Vascular, Stroke, Anticongulants, Antiplatelets
Number of references:
109
