Supervisors info:
Κωνσταντίνος Ν. Συρίγος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Νικόλαος Καβαντζάς, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αικατερίνη Πολίτη, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Summary:
INTRODUCTION: Lung cancer accounts for 27% of all cancer deaths in both men and women. Its diagnosis is initially imaging, further determined histologically, thereby defining the stage, local or non-extensive disease, that is metastases to both ipsilateral intrapulmonary and/or mediastinal lymph nodes respectively and accordingly to further treatment and prognosis.
PURPOSE: To correlate the histological type in early, up to three centimeters, of non-small cell lung cancer, with the presence of lymph node metastases.
MATERRIALS AND METHODS: This is a retrospective census of patients selected from the archives of the Thoracic Surgery Department of the General Hospital of Thoracic Diseases "Sotiria". We recruited 200 patients, mean age 65,65 years, of separately 2015 year and 2019 year, with non-small cell lung cancer, stage T1,N1/N2,M0, according to 8th edition of Tumour Node Metastasis classification, correlating its histologic type with the presence of lymph node metastases. Patients were operated on by 5 different thoracic surgeons and the preparations were reviewed by different pathologists.
RESULTS: Of the 200 patients, 46 developed both intrapulmonary and mediastinal lymph node metastases. We found that the main subtype is invasive adenocarcinoma, followed by squamous cell carcinoma, which associated with age over 65 years, tumors greater than two centimeters that approached visceral pleura without invading it, with high mitotic activity, and low differentiation, had a lymph node metastases up to 23%.
CONCLUSION: The results of our study were consistent with those of the world literature. Due to the non-negligible lymph node involvement, regardless of the histological type, even in tumors up to three centimetres, radical tumor and lymph node resection, are the gold standard for delaying the onset of lymphatic recurrence and achieve the maximum of the five-year, disease free survival rate.
