Unit:
Τομέας ΚλινικοεργαστηριακόςLibrary of the School of Health Sciences
Dissertation committee:
Αικατερίνη Πολίτη, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπουσα
Ελένη Καρβούνη, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Σταμάτιος Θεοχάρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ανδρέας Λάζαρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Παναγιωτίδης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεωργία Θωμοπούλου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Στρατηγούλα Σακελλαρίου, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Βλεννοπαράγωγα κυστικά νεοπλάσματα παγκρέατος. Μορφολογική, ανοσοκυτταροχημική προσέγγιση σε κυτταρολογικό υλικό
Translated title:
Mucinous cystic pancreatic neoplasms: cytomorphologic and immunocytochemical approach on cytologic material
Summary:
OBJECTIVES: This study aims to evaluate the performance of clinical, imaging and cytopathological criteria in the identification of high-grade dysplasia/carcinoma (HGD/Ca) in pancreatic mucin-producing cystic neoplasms.
METHODS: Sixty-eight consecutive, histopathologically confirmed mucin-producing cystic neoplasms, evaluated by EUS-FNA, were enrolled; specifically, 39 branch duct intraductal papillary mucinous neoplasms (BD-IPMNs), 21 main duct (MD-IPMN) and eight mucinous cystic neoplasms (MCNs). The associations between HGD/Ca in histopathology and findings of EUS and cytology, demographic, lifestyle and clinical parameters were evaluated, separately in IPMNs and MCNs.
RESULTS: Age ≥65 years was associated with HGD/Ca in IPMNs. In BD-IPMNs, cyst diameter ≥3 cm (sensitivity = 68.8%, specificity = 65.2%), a mural nodule (sensitivity = 56.3%, specificity = 78.3%), main pancreatic duct diameter 5-9 mm (sensitivity = 50.0%, specificity = 87.0%) and suspicious cytology (sensitivity = 81.3%, specificity = 100%) signaled the presence of HGD/Ca. Similarly, in MD-IPMNs, suspicious cytology predicted HGD/Ca with high sensitivity (88.9%) and excellent specificity (100%). Regarding cytopathological criteria, in BD-IPMNs, HGD/Ca was associated with high N:C ratio, background necrosis, presence of papillary structures, hypochromatic nuclei, hyperchromatic nuclei and major nuclear membrane irregularities (thickening and/or indentations).
CONCLUSIONS: Clinical, imaging and cytopathological criteria are useful in the identification of HGD/Ca in IPMNs.
Main subject category:
Health Sciences
Keywords:
Intraductal papillary mucinous neoplasm, Mucinous cystic neoplasm, Grade, Cytopathology, EUS-FNA
Number of references:
282
