Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Melexopoulou Christina
Dissertation committee:
Τούσουλης Δημήτριος,Καθηγητής, Ιατρική Σχολή, Ε.Κ.Π.Α
Βλαχάκος Δημήτριος, Καθηγητής, Ιατρική Σχολή, Ε.Κ.Π.Α
Μπολέτης Ιωάννης, Καθηγητής , Ιατρική Σχολή, Ε.Κ.Π.Α
Φιλιππάτος Γεράσιμος, Καθηγητής, Ιατρική Σχολή, Ε.Κ.Π.Α
Τσιούφης Κωνσταντίνος, Καθηγητής, Ιατρική Σχολή, Ε.Κ.Π.Α
Σιάσος Γεράσιμος, Αναπληρωτής Καθηγητής , Ιατρική Σχολή, Ε.Κ.Π.Α
Μαρινάκη Σμαράγδη, Επίκουρη Καθηγήτρια , Ιατρική Σχολή, Ε.Κ.Π.Α
Original Title:
Η επίδραση της μεταμόσχευσης νεφρού από ζώντες και αποβιώσαντες δότες σε καθιερωμένους και νεότερους βιοδείκτες καρδιαγγειακού κινδύνου
Translated title:
The effect of kidney transplantation from living and deceased-donors to conventional and novel biomarkers of cardiovascular disease
Summary:
Background. Cardiovascular disease remains the leading cause of death after kidney transplantation. Notably, cardiovascular risk is increased in the early post-transplant period, especially in kidney transplant recipients from deceased compared to those of living donors.
Methods. In this prospective study we evaluated proprotein convertase subtilisin/kexin type 9 (PCSK9), a newly recognized biomarker of cardiovascular risk and interleukin (IL)-6, a biomarker of inflammation, in the early post-transplant period. A total of eighty-three (83) patients with end-stage renal disease (ESRD) were enrolled. Ten out of them remained on the waiting-list and served as control group. Seventy-three patients were transplanted, half of them from a living and the others from a deceased donor. PCSK9 and IL-6 were assessed pre-transplantation (day 0), at 1 month and at 6 months post-transplantation.
Results. We observed an increase in PCSK9 levels after transplantation that persisted for 6 months (p<0.001). During the same period, IL-6 levels were significantly reduced. There was no correlation between PCSK9 and IL-6 levels during follow-up while differences were observed between living and deceased-donor recipients both in the levels of PCSK9 and in the other inflammatory biomarkers. Delayed graft function (DGF) was altered in relation to IL-6 levels in deceased-donor transplants.
Conclusions. Notably, biomarkers of systemic inflammation are improved early after transplantation, especially in living-donor recipients, while PCSK9 still remains increased. The period after transplantation is crucial since any kidney injury during this time can affect long-term outcome. Early interventions could probably be beneficial for long-term transplant and recipient outcomes.
Main subject category:
Health Sciences
Keywords:
Kidney transplantation, PCSK9, C-reactive protein, Interleukin-6, Delayed graft function, Inflammation, Biomarkers
Number of references:
150
