Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Dissertation committee:
Σαμπατάκου Ελένη, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ Επιβλέπουσα
Γιαμαρέλλος - Μπουρμπούλης Ευάγγελος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Παπαδόπουλος Αντώνιος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Τσιόρδας Σωτήριος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σαμάρκος Μιχαήλ, Αναπληρωτής Καθηγητης, Ιατρική Σχολή, ΕΚΠΑ
Ψυχογιού Μήνα, Επικουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Πουλάκου Γαρυφαλλιά, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Επιδημιολογία λοιμώξεων δέρματος - μαλακών μοριών
Translated title:
Epidemiology of skin-skin structure infections
Summary:
Introduction: The epidemiology of acute bacterial skin and soft tissue infection (ABSSSI) in Greece is not known. Methods: From November 2014 to December 2016, all admissions for ABSSSIs in 16 departments of internal medicine or surgery in Greece were microbiologically screened. Samples were cultured using conventional media; expression of the SA442, mecA/mecC and SCCmec/orfXjunction genes was assessed. Following univariate and forward logistic regression analysis, clinical characteristics were used to develop scores for prediction of the likely pathogens with at least 90% specificity. Results: 1,027 patients were screened and 633 had positive microbiology. Monomicrobial infections by Gram-positive cocci occurred in 52.1%, by Gram-negative bacteria in 20.5% and by mixed Gram-positive cocci and Gram-negative bacteria in 27.3%. The most common isolated pathogens were Staphylococcus aureus and coagulase-negative staphylococci. The resistance to methicillin was 57.3% (53.5-61.1%). Three scores were developed: one for infection by methicillin-resistant S.aureus incorporating recent hospitalization, atrial fibrillation, residency in long-term care facility (LTCF) and stroke; one for both Gram-positive and Gram-negative infections incorporating localization of ABSSSI at the lumbar area, recent fluoroquinolone intake, residency in LTCF and stroke; and another for Gram-negative infections incorporating ulcer presentation of the ABSSSI, peptic ulcer and solid tumor malignancy. Conclusions: Staphylococci resistant to methicillin are the main pathogens of ABSSSIs. Clinical characteristics may predict the most likely pathogens.
Main subject category:
Health Sciences
Keywords:
Skin infections, Methicillin resistance, Prediction score
File:
File access is restricted only to the intranet of UoA.
Nodaras Christos PhD.pdf
1 MB
File access is restricted only to the intranet of UoA.
