Κατεύθυνση Επεμβατική Καρδιολογία
Library of the School of Health Sciences

2020-06-23

2020

Gkoliopoulou Athina

Δημήτριος Τούσουλης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Ελένη Κυρίτση, Ομότιμη Καθηγήτρια, Τμήμα Νοσηλευτικής, Τ.Ε.Ι. Αθήνας
Κωνσταντίνος Τούτουζας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Σχέση οστεοπροτεγερίνης και αδιπονεκτίνης με τα ανευρύσματα και το διαχωρισμό ανιούσης θωρακικής αορτής

Greek

Relationship of osteoprotegerin and adiponectin with ascending thoracic aortic aneurysms and dissection

Introduction: Ascending aortic aneurysms and dissections are among the cardiovascular diseases with the highest mortality rates. There is, therefore, the need to investigate possible methods, such as easily detectable biomarkers, to facilitate their detection and follow-up. Osteoprotegerin and adiponectin are molecules proven to participate in the pathogenesis of cardiovascular diseases. However, their possible role in aortic aneurysms has not yet been studied.
Purpose: The purpose of the study is to examine a possible correlation of serum osteoprotegerin and adiponectin levels with aortic dilatation and ascending aortic dissection.
Methods: Serum samples were obtained from all patients preoperatively and osteoprotegerin and adiponectin levels were measured with ELISA method.
Results: This clinical study included 45 patients who had cardiac surgery in “Hippokrateion” General Hospital of Athens. 19 patients had an ascending aortic aneurysm or dilatation, 10 patients had acute ascending aortic dissection and 16 were patients with normal aortic diameter, undergoing cardiac surgery for other indications (control group). The study revealed a significant association between the examined groups of patients and levels of osteoprotegerin, with osteoprotegerin levels found to be increased in patients with acute ascending aortic dissection compared to patients with uncomplicated ascending aortic aneurysms (p=0.03), whereas there was no statistically significant difference between patients with ascending aortic aneurysms and the control group (p=0.34). No statistically significant difference was found between adiponectin levels of the different groups of examined patients.
Conclusions: In this study, osteoprotegerin was found to be associated with ascending aortic dissection yet not with uncomplicated ascending aortic aneurysms. This novel information might suggest osteoprotegerin participation in aortic dissection but not in aortic dilatation. Therefore, detection of elevated osteoprotegerin levels in patients with diagnosed ascending aortic aneurysms might suggest an increased probability of dissection and, hence, aid the decision-making process that physicians go through facing such patients.

Health Sciences

Osteoprotegerin, Adiponectin, Aneurysms, Aortic dissection

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https://pergamos.lib.uoa.gr/uoa/dl/object/2917179