Faculty of Medicine
Library of the School of Health Sciences

2020-06-29

2020

Pianou Nikoletta

Κελέκης Νικόλαος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Παπίρης Σπυρίδων, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χατζηϊωάννου Σοφία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπουσα
Αλεξοπούλου Ευθυμία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Μαλαγάρη Αικατερίνη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Λουκίδης Στυλιανός, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μάναλη Ευφροσύνη, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ

Ο ρόλος της Τομογραφίας Εκπομπής Ποζιτρονίων με 18-φθοριο-δεσοξυ-γλυκόζη (18F-FDG PET/CT) στη διαχείριση ασθενών με σαρκοείδωση και θωρακική νόσο

Greek

Utility of 18F-fluoro-2-deoxyglucose positron-emission tomography/computed-tomography (18F-FDG-PET/CT) in the evaluation of lung sarcoidosis

In this thesis we study the possible utility of 18F-fluoro-2-deoxyglucose positron-emission tomography/computed-tomography (18F-FDG-PET/CT) in the evaluation of lung sarcoidosis. In sarcoidosis progressive pulmonary disease affects prognosis. Pulmonary disease activity estimated by classic means poorly predicts severity and progressiveness. 18F-FDG-PET/CT estimates pulmonary activity by inflammatory-cells metabolism.
We aimed to investigate pulmonary sarcoidosis by the 18F-FDG-PET/CT and evaluate the role of total lesion glycolysis (TLG) value, as an index quantifying the whole burden of lung inflammation.
From a Greek cohort of 195 sarcoidosis patients, 87 were identified with lung increased 18F-FDG uptake and further studied. Visualizing lung by 18F-FDG-PET/CT identified new imaging patterns and revealed activity in all Scadding stages.
Ever-smokers presented significantly higher TLG and lower diffusing capacity of lung for carbon monoxide (DLCO) values compared to never-smokers. However, the TLG value did not correlate with functional indices and did not differ between symptomatic and non-symptomatic patients. Among treatment naïve patients, TLG did not differ significantly in those requiring therapy compared to those remained off.
In conclusion, 18F-FDG PET/CT improved imaging and detection of pulmonary involvement and through TLG value revealed the deleterious effect of smoking. The fact that the TLG neither detected patients with clinical symptoms and functional impairment nor identified those requiring treatment once again confirms that in pulmonary sarcoidosis the link between activity, severity and decision to treat still eludes us.

Health Sciences

18F-FDG-PET/CT, Total lesion glycolysis value, Sarcoidosis pulmonary activity, Smoking, SUV

No

0

Yes

184

142

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https://pergamos.lib.uoa.gr/uoa/dl/object/2917592