Unit:
Κατεύθυνση Αναπαραγωγική-Αναγεννητική ΙατρικήLibrary of the School of Health Sciences
Author:
Stathis Theofanis
Supervisors info:
Δρακάκης Πέτρος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ντόμαλη Αικατερίνη, Αν. Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Μαυρογιάννη Δέσποινα , ΕΔΙΠ, ΕΚΠΑ
Original Title:
Η έκφραση του DAZL σε τραχηλικά κύτταρα σε φυσιολογικούς τραχήλους και σε τραχήλους με HPV λοίμωξη
Translated title:
DAZL gene expression in cervical cells, in normal cervices and in cervices with HPV infection
Summary:
Introduction: DAZL gene is located on chromosome 3, has only one DAZ repetition and is called DAZL1 or DAZLA. DAZL gene is highly homologous to DAZ gene. Both DAZ and DAZL genes are expressed during most of the lifetime of germ cells and are required for the development of primordial germ cells, the differentiation and maturation of germ cells.
Purpose: The purpose of this study was to review literature on DAZL gene and το determine whether DAZL gene is expressed in cervical cells, in normal cervices and in cervices with HPV infection.
Material and Methods: Our sample consisted of 70 women aged 20-64 years, who were divided into two groups. Group A included 35 women, with histologically confirmed cervical HPV infection (in various stages). Group B consisted of 35 healthy women (histologically confirmed normal cervix). Immunohistochemical control was performed in the biopsy sample and the answers of the questionnaire were also analyzed.
Results: DAZL gene is not expressed in the cervical cells neither of healthy, nor of HPV infected cervices. From the questionnaire, correlations of HPV infection to several known risk factors were established, the most important being the consistency in the use of condoms during sexual intercourse.
Conclusions: DAZL gene is not expressed in the cells of normal cervices and cervices with HPV infection.
Main subject category:
Health Sciences
Keywords:
DAZ, DAZL, HPV infection, Immunohistochemistry
