Unit:
Κατεύθυνση Σύγχρονη Διαγνωστική στη Δερματολογία-Αφροδισιολογία και ΑλλεργιολογίαLibrary of the School of Health Sciences
Author:
Sarafopoulos Andreas
Supervisors info:
Αλέξανδρος Κατούλης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δημήτριος Ρηγόπουλος, Καθηγητής , Ιατρική Σχολή, ΕΚΠΑ
Σταμάτιος Γρηγορίου, Επικ. Καθηγητής , Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Μετωπιαία ινωτική αλωπεκία και συννοσηρότητες. Τι δηλώνουν για την παθογένεια του νοσήματος
Translated title:
Frontal fibrosing alopecia and comorbidities. What does this suggest regarding the pathogenesis of the disease.
Summary:
Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia occurring predominantly in white postmenopausal women. The last decade the incidence of FFA has increased significantly. The disease characterized by a progressive band-like recession of the frontotemporal hairline and eyebrows loss as well as eyelash loss and body hair loss. The purpose of this study is to find and determine the prevalence of diseases co-existing with FFA and what does this suggest regarding the pathogenesis of the disease.
Methods : We studied 45 cases diagnosed with FFA. All patients were examined during the period 2015 - 2019 at the Second University Clinic at Attikon Hospital. The diagnosis was made by patient’s history and typical clinical clues of the disease and in some cases was confirmed histologically.
Results : Patients were all women with an average age of first visit 63.9 years Post-menopausal: 40 (88%), pre-menopausal: 5 (1.2%). FFA with hypothyroidism was observed in 11 (24.4%) patients while Hashimoto's thyroiditis [(+) ATA] in 6 (13.3%) patients. Other autoimmune diseases were vitiligo (3 patients, 6.6%), psoriasis (1 patient, 2.2%), lichen planus (2 patients, 4.4%), rosacea (2 patients, 4%) and localized scleroderma (1patient, 2.2%). 27(60%) patients had androgenetic alopecia (AGA), 12 (26.6%) dyslipidaemia, 10 (22.2%) hypertension, 7 (15.5%) diabetes type 2 and 4(8,8%) osteoporosis.
Conclusions : The results of our study revealed a strong association between thyroid disease and FFA. Coexistence with other autoimmune diseases support an immunologic cause of this disease. Because of the similar genetic and environmental factors among the autoimmune diseases, patient with one autoimmune disease can develop other concomitant autoimmune disorders. (poly-autoimmunity).
Main subject category:
Health Sciences
Keywords:
Frontal fibrosing alopecia, Comorbidities, Autoimmunity, Cicatricial alopecia
