Unit:
Κατεύθυνση Επιστήμη Πολυμερών και Εφαρμογές της στη ΒιομηχανίαLibrary of the School of Science
Author:
Liakopoulou Melina
Supervisors info:
Ιατρού Ερμόλαος Καθηγητής ΕΚΠΑ
Πιτσικάλης Μαρίνος, Καθηγητής ΕΚΠΑ
Σακελλαρίου Γεώργιος, Αναπληρωτής Καθηγητής ΕΚΠΑ
Original Title:
Σύνθεση και Χαρακτηρισμός του Ν-καρβόξυ ανυδρίτη της Νε- φλουορενυλομεθοξυκαρβόνυλο-L-λυσίνης και των προστατευμένων και αποπροστατευμένων ομοπολυμερών Πολυ-(Νε-Fmoc-L-Λυσίνης) και Πολυ(L- λυσίνης).
Translated title:
Synthesis and Characterization of N-carboxy anhydride of Ne- fluorenylmethoxycarbonyl-L-lysine and protected and deprotected homopolymers Poly- (Ne-Fmoc-L-Lysine) and Poly (L- lysine).
Summary:
In this dissertation is presented the synthesis and the characterization of Νε-Fmoc-L-Lys NCA and poly-(Νε-Fmoc-L-Lys)3250, poly-(Νε-Fmoc-L-Lys)10000 copolymers, as well as their selective distillation with distilled piperidine. The synthesis of these polymers was conducted via Ring Opening Polymerization of the corresponding protected N-Caboxy Anhydride and n-hexylamine was used as the initiator. High Vacuum Techniques were used both for the purification of the solvents and the polymerizations, avoiding undesirable side reactions. The desirable polymers were characterized by Size Exclusion Chromatography (SEC/GPC), Nuclear Magnetic Resonance (NMR) and Fourier Transform Infrared Spectroscopy (FT-IR). Finally, the surface charge of nanoparticles was studied via zeta potential measurements. The ultimate goal of this study is the formation of stimuli responsive nanostructures that can incorporate anticancer drugs and selectively release them to desired destinations such as cancer tissues.
Main subject category:
Science
Keywords:
stimuli responsive polypeptides, N-carboxy anhydrides, ring opening polymerization, high vacuum techniques, dug delivery
