Unit:
Department of ChemistryLibrary of the School of Science
Author:
Koukoulakis Konstantinos
Dissertation committee:
Νικολέλης Δημήτριος, Καθηγητής, Τμήμα Χημείας, ΕΚΠΑ
Σκούλλος Μιχαήλ, Καθηγητής, Τμήμα Χημείας, ΕΚΠΑ
Μπακέας Ευάγγελος, Αναπληρωτής Καθηγητής, Τμήμα Χημείας, ΕΚΠΑ
Δασενάκης Εμμανουήλ, Καθηγητής, Τμήμα Χημείας, ΕΚΠΑ
Οικονόμου Αναστάσιος, Καθηγητής, Τμήμα Χημείας, ΕΚΠΑ
Κόκκινος Χρήστος, Επίκουρος Καθηγητής, Τμήμα Χημείας, ΕΚΠΑ
Λεοντιάδης Λεόντιος, Ερευνητής Α', ΕΚΕΦΕ ΔΗΜΟΚΡΙΤΟΣ
Original Title:
Μελέτη μετασχηματισμού ανθρωπογενών ατμοσφαιρικών ρύπων στην ατμόσφαιρα και σε βιολογικά υγρά
Translated title:
Study on the transformation of anthropogenic atmospheric pollutants in atmosphere and biological fluids
Summary:
The present thesis focuses in the study of atmospheric pollutants and their transformation in atmosphere and biological fluids. In this perspective, Persistent Organic Pollutants - POPs (Polycyclic Aromatic Hydrocarbons, Polychlorinated Biphenyls, Organochlorine Pesticides), metals and POPs’ metabolites (Hydroxylated - Polycyclic Aromatic Hydrocarbons) have been studied in atmosphere of Greece and in human serum of patients with leukemia cancer and healthy donors’ serum. Thus, an attempt for the investigation of any possible relation between air pollution and risk of leukemia in Greece has been performed.
For this scope, methods for the determination of the pollutants in human serum have been developed and validated while a full scan analysis has also been applied for the qualitative characterization of patients’ metabolic profile using very sensitive and precise techniques (Gas Chromatography-Mass Spectrometry or Mass Spectrometry/Time Of Flight). Metals’ analysis has been performed by Inductive Coupled Plasma-Mass Spectrometry (ICP/MS)
Statistical analysis of the results using appropriate software and different statistical tools has revealed serious atmospheric degradation in different sites of Greece. Moreover, POPs, metabolites and metals presented significant variations in their concentrations between patients’ and healthy donors’ serum while smoking habit and environmental factors like area of residence found to play crucial role in analytes’ serum levels. The “environmental footprint” in relation with one of the most complicated type of cancer and their subtyped studied for the first time in Greece.
In conclusion, this thesis indicates that air quality in many sites of Greece needs extensive monitoring because air pollutants levels may lead to undesirable health implications and more specifically a strong association among air pollutants and their metabolites with adult leukemia risk has been investigated, suggesting the monitoring of their levels in serum as a potential biomarker.
Main subject category:
Science
Keywords:
Atmospheric pollutants, metabolites, metals, Persistent Organic Pollutants, leukemia
Number of references:
494
