Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Mantonakis Eleftherios
Dissertation committee:
Πικουλής Εμμανουήλ, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Φελέκουρας Ευάγγελος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Θεοχάρης Σταμάτιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δημητρούλης Δημήτριος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Πατάπης Παύλος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Παπακωνσταντίνου Ιωάννης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αλεξάνδρου Ανδρέας, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Κλινική σημασία της έκφρασης των πρωτεϊνών FAK, Src και Paxillin σε ηπατικές μεταστάσεις από ορθοκολικό καρκίνο
Translated title:
Clinical significance of FAK, Src and Paxillin expression in hepatic metastases from colorectal cancer
Summary:
The FAK/Src/Paxillin axis has been implicated in malignant transformation, tumor growth, progression and metastasis. The present study aimed to assess FAK, Src and Paxillin (PXN) protein expression in both primary and liver metastatic sites of colorectal adenocarcinoma (CRC). FAK, Src and p-PXN expression was assessed immunohistochemically on 32 primary CRCs and their corresponding liver metastases, being also analyzed in relation with clinicopathological characteristics and patient survival. Increased FAK expression in primary CRCs was significantly associated with poor histological grade and advanced disease stage (p=0.0330 and p=0.0204, respectively). Increased Src expression in primary colorectal tumors was significantly associated with the presence of lymph node metastasis (p=0.0325), while elevated p-PXN expression with poor histological grade (p=0.0284). FAK, Src and p-PXN expression was significantly decreased in liver metastasis compared to matched paired primary CRCs (p<0.0001). FAK, Src and p-PXN appear to play a role in the pathophysiological aspects of CRC, with significant difffences in their expression between primary and secondary sites. These differences could be attributed to altered functionality in the specific sites at the time examined and to differences in the tumor microenviroment. The lower expression of these proteins in liver metastasis compared to the primary CRC could significantly impact the choice of a novel therapeutic agent according to the disease stage.
Main subject category:
Health Sciences
Keywords:
FAK, Src, Paxillin
Number of references:
376
File:
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Mantonakis Eleftherios PhD.pdf
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