Pergamos - Library and Information Center of National and Kapodistrian University of Athens

Unit:

Κατεύθυνση Κλινικές Μελέτες: Σχεδιασμός και Εκτέλεση
Library of the School of Health Sciences

Deposit date:

2020-09-02

Year:

2020

Author:

Xenou Dimitra

Supervisors info:

Τέρπος Ευάγγελος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ψαλτοπούλου Θεοδώρα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Σταματελόπουλος Κίμων, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Original Title:

Διατροφικές παράμετροι και καρκίνος της ουροδόχου κύστης: συστηματική ανασκόπηση και μετά ανάλυση προοπτικών μελετών

Languages:

English

Translated title:

Dietary parameters and bladder cancer: a systematic review and meta-analysis of prospective cohort studies

Summary:

We examined the association between fruit/vegetable consumption and bladder cancer (BC) risk in a systematic review and meta-analysis of prospective cohort studies, stratifying results by gender, smoking status and geographical region. Eligible studies were sought in MEDLINE and EMBASE up to April 20, 2020. Random-effects (Der Simonian-Laird) models were implemented for the calculation of pooled relative risks (RRs) and 95% confidence intervals (CI). Fifteen eligible studies were identified (1,855,277 subjects, 125,029 BC cases). Vegetable consumption (pooled RR=0.95, 95% CI:0.87-1.04, n=10) as well as combined fruit/vegetable consumption was not associated with BC risk. Regarding fruit intake, the overall protective trend did not reach significance (pooled RR=0.91, 95%CI: 0.81-1.02, n=11); we found however a significant association in East Asians. A trend towards a protective association with citrus fruit consumption was also noted (pooled RR=0.83, 95%CI: 0.69-1.01, n=6), once again with a significant effect in East Asians. Moreover, no association was found regarding the subgroups of leafy vegetables, dark green vegetables, and berries. Single study arms pointed to a reduced BC risk in never smoking males consuming cruciferous vegetables and East Asians consuming yellow vegetables. In conclusion, our study reveals possible protective effects; larger studies are needed to investigate the emerging trends.

Main subject category:

Health Sciences

Keywords:

Fruits, Citrus, Yellow vegetable, Cruciferous, Bladder cancer, Meta analysis, Meta regression

Index:

Number of index pages:

Contains images:

Yes

Number of references:

120

Number of pages:

174