Supervisors info:
ΕΠΙΒΛΕΠΩΝ: Βασίλειος Κουλουλίας, Αναπλ. Καθηγητής Ιατρικής Σχολής ΕΚΠΑ
ΜΕΛΟΣ: Μαρία Τόλια, Επικ. Καθηγήτρια Ιατρικής Σχολής Πανεπιστημίου Θεσσαλίας
ΜΕΛΟΣ: Πέτρος Μπακάκος, Αναπλ. Καθηγητής Ιατρικής Σχολής ΕΚΠΑ
Summary:
Introduction
Lung cancer is the leading cause of cancer mortality, with over 1 million deaths every year worldwide. A large proportion of cases are diagnosed at locally advanced stage (III). Radiotherapy (RT) has been shown to improve local-regional disease control and overall survival in these patients.
Aim
This study evaluated the toxicity caused by RT techniques such as 3D-CRT (Three-Dimensional Conformal Radiotherapy) and IMRT (Intensity-Modulated Radiotherapy) in locally advanced lung cancer patients.
Materials and Methods
A retrospective observational study was performed. Thirty patients (96,7% male and 3,3% female) with Locally Advanced Non-Small Cell Lung Cancer that underwent radiotherapy, during the last 4 years, were enrolled. The database of the 3rd Pathological Department - Oncology Unit, of Sotiria Chest Hospital. The patient stages were IIB (6,7%), IIIA (63,3%), IIIB (26,7%) and IIIC (3,3%). 22 cases (73,3%) were treated with concurrent and 8(26,7%) with sequential chemotherapy. All patient received radiation using IMRT (60%) or 3D-CRT (40%) technique.
Results
The median follow up was 6 months (range, 3-9 months) after the treatment. The overall survival rate was 90% the first year, 50% for the second and 26,7% the third year for all of the patients. Progression-free survival was 43,3% and 10% for the first and the second year respectively, resulting in a median PFS of 13 months.
The most common side effects caused by radiation were anemia 76,7%, cough 40%, pulmonary fibrosis 33,3%, radiation pneumonitis 30%, esophagitis 20%, dyspnoea 23,3%, nausea 23,3%, pericarditis 16,7% and rib fracture 10%.
Conclusion
Combined chemo-radiotherapy was associated with a higher complete pathological response rates, free surgical margins, although a greater but not severe toxicity.
Keywords:
Non-small cell lung cancer, Locally advanced, Radiotherapy, Toxicity, 3D-Σύμμορφη ΑΚΘ, MRT, IGRT, SBRT
