Unit:
Κατεύθυνση Θρόμβωση-Αιμορραγία-Ιατρική των μεταγγίσεωνLibrary of the School of Health Sciences
Supervisors info:
Παρασκευή Ματσώτα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αργυρή Γιαλεράκη, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ελισάβετ Γρουζή, Διδάκτωρ, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Συστηματική φλεγμονώδης αντίδραση στην εξωσωματική κυκλοφορία. Ο ρόλος των ΝΕΤς.
Translated title:
Systemic inflammatory response syndrome in extracorporeal circulation. The role of NETs.
Summary:
The evolution of cardiac surgery, the discovery of Cardiopulmonary Bypass machine along with Mechanical Circulatory Devices since 1950, have made cardiac procedures safe, improved the quality and longevity of life of patients.
Extracorporeal Circulation makes multiple changes in normal circulation of blood and organ function causing production of inflammatory mediators. With the improvement in surgical techniques and technology evolution, many of the undesirable reactions of the body to Extracorporeal Circulation have been decreased. Nevertheless, the Systemic Inflammatory Response Syndrome in Extracorporeal Circulation remains one of the main causes of organ dysfunction in patients undergoing cardiac surgery.
Systemic Inflammatory Response Syndrome is mainly initiated from blood contact to surface other than endothelium, such as the cardiopulmonary bypass circuit. From blood contact to “foreign” surface a series of reactions are initiated that includes absorption of proteins, initiation of coagulation system, of complement system activation of platelets, leucocytes and neutrophils. Lately, there is a great interest from researchers for the role of Neutrophils and the produced Neutrophil Extracellular Traps (NETs) in the development of SIRS and of its treatment.
In this study, there are descriptions of mechanisms of the development of SIRS, and methods used for the treatment, and implications of the role of NETs, as they are found in published research projects.
Main subject category:
Health Sciences
Keywords:
Systemic inflammatory response syndrome, Extracorporeal circulation, NETs
Number of references:
112
