Unit:
Κατεύθυνση Κλινική Παιδιατρική & Νοσηλευτική - ΈρευναLibrary of the School of Health Sciences
Supervisors info:
Πονς Ροντριγκεθ Μαρία Ροζέ, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Σιαχανίδου Σουλτάνα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Κουτελέκος Ιωάννης, Επίκουρος Καθηγητής, Τμήμα Νοσηλευτικής, Πανεπιστήμιο Δυτικής Αττικής
Original Title:
Συγχρονική μελέτη εμφάνισης διαταραχών κινητικότητας σε βρέφη και παιδιά με επιληπτική εγκεφαλοπάθεια
Translated title:
A cross-sectional study of movement disorders in infants and children with epileptic encephalopathy
Summary:
Introduction: The epileptic encephalopathies are severe brain disorders that characterized by frequent epileptic seizures and associated with psychomotor delay or mental retardation. The main causes are genetic, neurometabolic, and acquired diseases as is ischemic encephalopathy after congenital infections and perinatal asphyxia. In some cases the causal factor is undetermined and they are referred as cryptogenic. It is a group of diseases that appears in infancy and in early childhood, accompanied by paroxysmal activity in EEG, different types of seizures which are difficult to control and neurological deficits. The appearance of movement disorders as additional features could comprise an important clue for an accurate and early diagnosis of encephalopathy.
Aim of the study: The aim of the study is to explore the characteristics of movement disorders in epileptic encephalopathies.
Methodology: It is a restropective cross-sectional study. This study included 58 patients, who have diagnosed with epileptic encephalopathy before the age of three and followed up in the Pediatric Neurology Unit in the Children’s Hospital “Agia Sofia” during the period 2014-2019.
Results: The etiology of the epileptic encephalopathy was in 40% of cases cryptogenic, in 33% genetic, in 15% the cause was a neurometabolic disease, and in 12% was acquired. The age of the onset of epileptic encephalopathy was in 55% of the patients at the infancy, in 26% at the neonate and in 19% at the toddlerhood (1-3 years). A 74% of the patients developed a type of movement disorder either hyperkinetic (dystonia, chorea, tremor and stereotypies) or rarely hypokinetic disorder, whereas the 26% of the patients had not developed any movement disorder.
Conclusion: Our study found that three out of four patients with epileptic encephalopathy had a type of movement disorder that correlated with the etiology.
Main subject category:
Health Sciences
Keywords:
Epileptic encephalopathies, Yyperkinesias
