Supervisors info:
Νικόλαος Σμυρνής, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Ζαλώνης, Αν. Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σωκράτης Παπαγεωργίου, Αν. Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Summary:
The purpose of this study was to examine except from cognitive deficits behavioral disturbances in patients with dementia by using the Frontal Systems Behavior Scale (FrSBe) for the first time in Greek population. To be more specific The Frontal Systems Behavior Scale (FrSBe) is a 46-item behavior rating scale that is intended to measure behavior associated with damage to the cortical and subcortical frontal systems of the brain, with subscales measuring Apathy, Disinhibition and Executive Dysfunction .In addition according to recent studies a better fit model removed 8 items has been proposed (3 items from apathy scale, 3items from disinhibition and 2 items from executive dysfunction).Therefore , in this study have been completed two measurements, one with original version and another one with the reduced version. The results indicated strong validity in both versions. Purpose of the current study was to evaluate the cut offs score of FrSbe and as a second hypothesis was to compare the performances between Frontotemporal dementia (FTD) patients, Alzheimer(AD) patients and normal subjectives to scales of FrSBe. The results have demonstrated quite satisfied cut offs for both versions. To be more specific, for total score in the original version the cut off was the 103,5 ( sensitivity 81%, specificity 79,6 %) and for reduced version 81,5( sensitivity 84% , specificity 77,8 %) .What is more, at apathy scale at the original version the cut off was 33,5(sensitivity77,9 % , specificity 70,4 %) and for reduced version the cut off was 26,5( sensitivity 81,6% , specificity74,1 %).With regard to executive dysfunction scale the cut off was 41,5 ( sensitivity 86,3 % , specificity 81,5 %) and 31,5 (sensitivity 85,8% , specificity 81,5 %), for original and reduced version respectively. Finally, for disinhinbition scale the cut off for the original model was 27,50 ( sensitivity 66,3% , specificity 61,1 %) and the 22,5 ( sensitivity 67,4 %, specificity 70,4 %) for the reduced model respectively. Refers to second hypothesis the results indicated differences at performances between dementia patients and healthy subjects. Furthermore, differences at performances have been noticed between AD and FTD patients.
Keywords:
Behavioral disturbances, Dementia, Frontal lobe, Frontal cortical-subcortical circuits, FrSBE
