Κατεύθυνση Παθολογία της Κύησης
Library of the School of Health Sciences

2020-09-25

2020

Tsochrinis Alexios

Παπαντωνίου Νικόλαος, Ομότιμος Καθηγητής, Ιατρική Σχολή, Ε.Κ.Π.Α.
Κασσάνος Δημήτριος, Ομότιμος Καθηγητής, Ιατρική Σχολή, Ε.Κ.Π.Α.
Χρέλιας Χαράλαμπος, Καθηγητής, Ιατρική Σχολή, Ε.Κ.Π.Α.

Μη επεμβατικός προγεννητικός έλεγχος πρώτου τριμήνου χρωμοσωμικών ανωμαλιών του εμβρύου και επιπλοκών της κύησης : Νεότερα δεδομένα

Greek

Non-invasive first trimester prenatal screening for fetal chromosomal abnormalities and pregnancy complications: Recent studies.

INTRODUCTION: Non-invasive prenatal screening methods include the use of specific biomarkers, either as independent prognostic factors, or in combination with specialized first trimester ultrasound and cffDNA testing, using the maternal serum.
METHOD: A literature search of the application of non-invasive prenatal screening methods, during the first trimester of pregnancy to clinical practice, was conducted, studying electronic databases such as Pubmed, Wikipedia, Uptodate, Medline, Google scholar using keywords.
RESULTS: Biomarkers, such as β-Hcg, PAPP-A, and PLGF, can be used as predictors of pregnancy-related pathological conditions, such as preeclampsia, preterm birth, and residual fetal development. Better results are offered with the combination of nuchal translucency’s measurement and the use of biomarkers. The cffDNA (NIPT) records high levels of sensitivity and specificity for the prognosis of the most common fetal chromosomal abnormalities. However, high false positive ratio is also recorded. Therefore, the confirmation of the positive results requires the use of invasive methods. Their application in clinical practice is very important for more intensive care of the high-risk pregnancies and for an optimal perinatal outcome.
CONCLUSIONS: Currently, first trimester non-invasive prenatal methods are excellent predictive tool for the most pregnancy-related pathological conditions, but they cannot be used as a diagnostic tool, yet.

Health Sciences

Preeclampsia, Combined test first trimester, Nuchal translucency, Nasal bone, Ductus venosus, Tricuspid valves, B-HCG, PAPP-A, PLGF, SFLT1, CFFDNA, NIPT, RHD, Trisomies, Aneuploidies, Chromosomal microdeletions

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https://pergamos.lib.uoa.gr/uoa/dl/object/2923309