Κατεύθυνση Αναπαραγωγική-Αναγεννητική Ιατρική
Library of the School of Health Sciences

2020-10-02

2020

Papanikolaou Ioannis

Πέτρος Δρακάκης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αικατερίνη Ντόμαλη, Αν. Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Δέσποινα Μαυρογιάννη, ΕΔΙΠ, Ιατρική Σχολή, ΕΚΠΑ

Διατήρηση γονιμότητας σε γυναικολογικό καρκίνο και ειδικές παθήσεις

Greek

Fertility preservation in gynaecological cancer and special diseases

Cancer diagnosis is a life-threatening condition which may affect every age. In the last years, cancer diagnosis affects an increasing number of women in reproductive age. When gynaecological cancer diagnosis occurs to a woman of reproductive age, she should know that chemotherapy drugs and radiotherapy display significant gonadotoxicity and may negatively affect the subsequent ovarian function and women’s reproductive potential. Therefore, there is a great chance that after the end of chemotherapy/radiotherapy the menstrual cycle may be disturbed or even stopped; a condition, which entails significant risks for failed conception or childbearing, for some groups of cancer survivors. Fortunately, the development of reproductive medicine may offer various alternatives for fertility preservation in these cases. Fertility preservation is possible using one of the following methods: oocyte cryopreservation, embryo cryopreservation, ovarian tissue cryopreservation, in vitro maturation of oocytes, pharmaceutical protection of the ovaries using GnRH agonists, ovarian translocation surgery prior to radiotherapy, in vitro fertilization with egg donation. Aforementioned methods are also used for fertility preservation purposes in certain other specific neoplastic conditions such as blood malignancies and pediatric cancers. Nowadays, fertility preservation options are also available for several non neoplastic conditions such as: lupus erythematosus, antiphospholipid syndrome, vasculitis, rheumatoid arthrytis, which usually include gonadotoxic treatments offered for therapy or prevention of sequelae. It should be highlighted that also these conditions and associated treatments may negatively affect woman’s reproductive potential. For that reason, fertility preservation options should be addressed also in patients affected from some of these conditions. Counseling for applicability of fertility preservation strategies, is mandatory and should be offered to all patients before the beginning of gonadotoxic treatments. Fertility preservation options should be adequately chosen, carefully measuring risks/benefits, safety, attended outcomes, maintaining an individualized patient-tailored approach.

Health Sciences

Fertility preservation, Gynaecological cancer, Special diseases, Gonadotoxic treatments, Oocyte cryopreservation, Embryo cryopreservation, Ovarian tissue cryopreservation, Ovarian transposition, GnRH analogues, Assisted reproduction techniques

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https://pergamos.lib.uoa.gr/uoa/dl/object/2923843