Supervisors info:
Κόκοτος Χριστόφορος, Αναπληρωτής Καθηγήτης, Τμήμα Χημείας, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Summary:
Photoorganocatalysis constitutes a new, fast moving and rapidly developing field of catalysis. In recent years, the scientific community has turned its focus on the development of milder, less expensive and more eco-friendly reagents and reaction conditions, in order to emphasize the turn towards Green Chemistry. The Laboratory of Organic Chemistry of the University of Athens has already developed many photochemical protocols for the synthesis of a wide variety of organic compounds, by utilizing light as the source of irradiation and organic molecules as catalysts.
In the current thesis, the first chapter consists of an introduction to Photochemistry, as well as to some key contributions to the field. In the second chapter, the activation of aldehydes and the importance of hydroxamic acids and esters as compounds are being reviewed, and selective methods for their synthesis, both traditional and newer ones, are mentioned. In the third chapter, the importance of benzimidazoles as compounds is being reviewed, and selective methods for their synthesis, both traditional and newer ones, are mentioned.
In this thesis, as discussed in chapter four, we intended to:
study the photochemical reaction for the activation of aldehydes and its application in the synthesis of hydroxamic acids, esters and the drug Moclobemide, as presented in the fifth chapter.
study the photochemical synthesis of benzimidazoles and its application in a variety of different substrates, as presented in the sixth chapter
Finally, in the seventh chapter the experimental procedures and the spectroscopic data of the synthesized compounds are described.
Keywords:
Photoorganocatalysis, Photochemistry, Green Chemistry, aldehydes, hydroxamic acids, esters, diamines, benzimidazoles
