Supervisors info:
Παγώνα Λάγιου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ.
Γκίκας Μαγιορκίνης, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ.
Φίλιππος Ορφανός, Μέλος ΕΔΙΠ, Ιατρική Σχολή, ΕΚΠΑ.
Summary:
Objective: Today, lung cancer is one of the most important public health problems, is the leading cause of cancer worldwide and the second leading cause of death worldwide after cardiovascular disease. Studies and literature review have so far shown, that the identification of the histological type of lung cancer contributes significantly to the selection, implementation of the specialized treatment, the staging and the course of disease. Also, various reports from the literature review and studies have shown that risk factors for lung cancer may be more or less aggravating for specific histological type of lung cancer. The aim of this study is to study whether there is a difference in the role of documented and non-documented risk factors in relation to small cell and non-small cell lung cancer.
Method: The study involved 400 patients with lung cancer. Newly diagnosed patients with lung cancer who have performed histological examination to identify the histological type. All patients responded to a brief medical history coming to the PET/CT laboratory of the Academy of Medical and Biological Research of the Academy of Athens for the PET/CT examination to stage the disease. The questionnaire included items such as age, gender, place of residence, smoking, number and year of cigarettes, pneumonia, tuberculosis, COPD, diabetes
Results: The study involved 400 patients with lung cancer. Males 77% (N=308) and 23% (N=92) females participated with an mean age of 67,45± 8,99 years with a minimum value of 35 and a maximum of 91 years. The majority of participants with a percentage of 72% (N=288) reported that they live in a city and 28% (N=112) in the province. Regarding the diseases which were reported in addition to presence of cancer 63.50% (N=254) reported that they did not carry, 18.25% (N=73) reported diabetes, 15.50% (N=62) pneumonia, 5.25% (N=21) COPD and 3% (N=12) tuberculosis. Furthermore for years of smoking that out sample stated, the average is 39.22 ±14.93 years with a minimum of 0 years and a maximum of 68 years. Regarding the number of cigarettes on average , patients smoke 29.12 ±16.90 cigarettes with a minimum price of 0 and a maximum of 100. Relative the type of lung cancer, majority at 59% (N=236) reported Adenocarcinoma, 36.25% (N=145) Squamous cell, 3% (N=12) Microcellular and 1.75 (N=7) Large cells.
Conclusion: From the aggravating factors, which studied for this study, their role as aggravators for the emergence of specific histological types is confirmed by age , gender, the presence of COP and combination of cigarettes and years of smoking. Also, is interesting the fact that not all diseases may be found in a significant correlation with a specific histological type, but the combination of diseases, 2 or more which the participants are blamed , show statistically significant dependence on specific histological types. In Adenocarcinoma the most important factor is the reduced age, while Squamous cell is increased age. The lowest percentages of Adenocarcinoma are observed in patients with COPD and the highest rates of Squamous cell type.
Keywords:
Lung, Adenocarcinoma, Squamus-cell, Cancer,Small-cell, Non-small-cell
