Unit:
Κατεύθυνση ΒιοστατιστικήLibrary of the School of Health Sciences
Supervisors info:
Ευαγγέλου Ευάγγελος, Επίκουρος Καθηγητής, Ιατρική Σχολή, Πανεπιστήμιο Ιωαννίνων
Κατσουγιάννη Κλέα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Τουλούμη Παναγιώτα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Μελέτες αλληλεπίδρασης γονιδίου - περιβάλλοντος για το μελάνωμα
Translated title:
gene - environment interactions for melanoma
Summary:
Background:Study of gene-environment interaction is important for improving accuracy and precision in the assessment of both genetic and environmental influences. Implementation of these studies usually requires a group of patients and a group of controls.However, the selection of the control group has been associated with problems.Thus, new methods, such as case-only analysis, have been created to study such interactions.The objective of this study is to compare the case-only and case-control designs using data from patients with melanoma.
Methods: We used data from UK Biobank. We studied 20 genetic polymorphisms that have been shown to be related to the risk of melanoma at a genome-wide level.1,038 people with melanoma and 321,570 healthy controls were enrolled.Using and comparing a case-control and a case-only design, we performed logistic regression analyses to investigate statistical interactions between each one genetic polymorphism and solar radiation.
Results:A genetic polymorphism was statistically significant at a significance level of 5x10-8. However, under the interaction models, no association found statistically significant leading to the conclusion that exposure to solar radiation and each of the 20 genetic polymorphisms separately did not have a common effect.
Conclusions: The small sample size and lack of power are the possible reasons why no significant interaction between the genetic and environmental factors has been identified.Our findings warrant further investigation in epidemiological and functional studies to aid in the development of recommendations for disease prevention.
Main subject category:
Health Sciences
Keywords:
Gene-environment interaction, Melanoma, Solar radiation, Genetic polymorphisms
