Κατεύθυνση Κλινικοπαθολογοανατομική θεώρηση των νεοπλασιών του ανθρώπου
Library of the School of Health Sciences

2020-11-03

2020

Tzortzaki Kleopatra

Ανδρέας Χ. Λάζαρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Καβαντζάς, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ειρήνη Θυμαρά, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ

PI3K/Akt/mTOR και καρκίνος του προστάτη: Σύγχρονη έρευνα, κλινικές μελέτες, θεραπεία

Greek

PI3K/Akt/mTOR and prostate cancer: Current research, clinical studies, treatment

The prostate gland is a part of the male reproductive system. Its main function is the secretion of prostate fluid that supports sperm. Prostate cancer is one of the most common types of cancer in men. Its development is usually slow and in the early stages it develops inside the gland, where it is not accompanied by severe symptoms. Although in some cases, due to its slow development, it may not require any treatment or require some minimal treatment, there are cases that it can spread more quickly and be more aggressive.
Despite recent diagnostic and therapeutic developments, the rate of the disease remains high. Most prostate cancers require androgens to grow and are therefore highly sensitive to androgen deprivation therapy (ADT) 1. However, this response is temporary and the majority of patients become resistant to androgen deprivation, leading to castration-resistant prostate cancer (CRPC). CRPC is characterized by persistent tumor growth despite serum testosterone deprivation levels, leading to a significant number of deaths.
At a cellular level, the development of CRPC represents a significant compensatory response to induced androgen deprivation, allowing cancer cells to survive and then succeed in thriving in a low-testosterone environment. There are many reports suggesting that compensation through signal pathways, represents another important mechanism for promoting CRPC development. The PI3K-Akt-mTOR signaling pathway emerges as a very important node that directs resistance to ADT and stimulates tumor growth under testosterone deprivation.
The purpose of this thesis is to provide an in-depth understanding of the molecular mechanisms that drive this process in order to be able to target the onset and evolution of CRPC.

Health Sciences

PI3K/Akt/mTOR, Prostate cancer, Castration resistant, Androgen deprivation therapy

No

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Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/2926883