Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Tziatzios Georgios
Dissertation committee:
Χατζηαγγελάκη Εριφύλη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Δημόπουλος Γεώργιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μπάμιας Αριστοτέλης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γιαμαρέλλος-Μπουρμπούλης Ευάγγελος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Παπανικολάου Ιωάννης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Τριανταφύλλου Κωνσταντίνος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Παπαδόπουλος Αντώνιος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Σύνδρομο βακτηριακής υπερανάπτυξης των μικροβίων του λεπτού εντέρου και λειτουργική δυσπεψία
Translated title:
Small intestinal bacterial overgrowth and functional dyspepsia
Summary:
Background/Aims: Small intestinal bacterial overgrowth (SIBO), characterized by either increased numbers or presence of colonic type bacteria in the small bowel has been previously described in Functional Dyspepsia (FD), based on breath testing. In this study, we aim to examine the prevalence of SIBO among FD patients using small bowel aspirate culture.
Methods: We prospectively enrolled outpatients fulfilling Rome IV criteria for FD. Severity of symptoms was graded using the patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM) questionnaire. Patients underwent upper gastrointestinal endoscopy and duodenal fluid was aspirated in sterile traps. SIBO was defined as ≥103 CFU/ml of duodenal aspirate and/or presence of colonic type bacteria. Patients undergoing gastroscopy due gastroesophageal reflux symptoms - control group (CG) - and patients with irritable bowel syndrome (IBS) fulfilling Rome IV criteria were also recruited.
Results: We enrolled 227 FD subjects, 30 CG and 90 IBS patients. Among FD patients, 144(63.4%), 64(28.2%) and 19(8.4%) had Postprandial Distress (PDS), Epigastric pain (EPS) and overlap PDS-EPS syndrome, respectively. SIBO prevalence was 20.8%, 12.5% and 31.6% among PDS, EPS and overlap PDS-EPS FD subtypes, respectively. Overall, SIBO prevalence was significantly higher in FD [44/227(19.4%)], compared to CG [1/30(3.3%)], (p=0.037) and similar to IBS [44/227(19.4%) vs. 15/90(16.7%), p=0.63] subjects. SIBO presence was associated neither with total nor with any subscale score of the PAGI-SYM questionnaire.
Conclusions: In a cohort of Greek FD patients, SIBO prevalence was similar to that of IBS subjects and higher compared to that of controls.
Main subject category:
Health Sciences
Keywords:
Functional dyspepsia, Bacterial overgrowth syndrome, Prevalence
Number of references:
248
