Κατεύθυνση Επιδημιολογία-Μεθοδολογία έρευνας στις βιοϊατρικές επιστήμες, την κλινική πράξη και τη δημόσια υγεία
Library of the School of Health Sciences

2021-02-24

2021

Jahaj Edison

Παγώνα Λάγιου, Καθηγήτρια, Ιατρική Σχολή, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών, Επιβλέπουσα
Αναστασία Κοτανίδου, Καθηγήτρια, Ιατρική Σχολή, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Φίλιππος Ορφανός, Μέλος ΕΔΙΠ, Ιατρική Σχολή, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών

Προγνωστικοί βιοδείκτες οξείας νεφρικής βλάβης σε ασθενείς στη Μονάδα Εντατικής Θεραπείας

Greek

Prognostic biomarkers of acute kidney injury in Intesive Care Unit patients

Introduction: Acute kidney Injury (AKI) is one of the most common problems in critically ill patients. It increases both morbidity and mortality in these patients. In recent years, studies have focused on finding new biomarkers for the early diagnosis and prognosis of AKI.
Objective: The aim of this study was to investigate prognostic biomarkers(NGAL and creatinine) of acute renal failure in critically ill patients in the Intensive Care Unit.
Material and Methods: The present study included 266 critically ill patients who admitted to the ICU. 98 of them developed AKI during ICU stay. ROC curves were applied to calculate the predictive accuracy of the biomarkers, as well as univariate and multivariate analysis.
Results: 75% of study population were men. The mean age of the population was 46.5 years old. Patients were divided in two groups based on the presence (N = 98) or not of acute renal injury (N = 168), during their stay in the ICU.
NGAL levels upon admission to the ICU were significantly higher between those who showed AKI and those who did not (192.9±155.2 and 107.9±80.27, p<0.0001) respectively. ROC analysis was performed to determine the prognostic accuracy of NGAL and creatinine. NGAL alone has been shown to be more accurate in predicting acute renal injury than creatinine or a combination of these. Univariate analysis showed that NGAL levels were associated with an increased risk of acute renal injury. The odds ratio (OR) and confidence interval were 1.006 (1.004-1.009), p <0.0001.
Conclusion: The present study showed that elevated NGAL levels on admission day are predictive for AKI during ICU hospitalization. Further studies are needed to indicate NGAL as a prognostic marker of acute renal injury.

Health Sciences

Acute kidney injury, Biomarkers, ICU, Creatinine, Prognosis, NGAL

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Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/2936890