Department of Pharmacy
Library of the School of Science

2021-05-31

2021

Papaioannou Foteini

Κουλάδη Μαρία, Καθηγήτρια, Τμήμα Φαρμακευτικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Μητάκου Σοφία, Καθηγήτρια, Τμήμα Φαρμακευτικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Ρούσσης Βασίλειος, Καθηγητής, Τμήμα Φαρμακευτικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Σκαλτσά Ελένη, Καθηγήτρια, Τμήμα Φαρμακευτικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Τζάκου Όλγα, Καθηγήτρια, Τμήμα Φαρμακευτικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Ιωάννου Ευσταθία, Επίκουρη Καθηγήτρια, Τμήμα Φαρμακευτικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Ταραντίλης Πέτρος, Καθηγητής, Τμήμα Επιστήμης Τροφίμων & Διατροφής του Ανθρώπου, Γεωπονικό Πανεπιστήμιο Αθηνών

Απομόνωση βιοδραστικών δευτερογενών μεταβολιτών από τα είδη Phlomis lycia D. Don, Thymus atticus Celak και Salvia fruticosa Mill. της οικογένειας Labiatae

Greek

Isolation of bioactive secondary metabolites from the species Phlomis lycia D. Don, Thymus atticus Celak and Salvia fruticosa Mill. of the family Labiatae

In the framework of the present PhD thesis, the chemical composition of the
organic extracts of three selected plants of the family Labiatae was investigated.
Specifically, the plants studied included (a) Phlomis lycia, whose aerial parts were
collected during the flowering season from native populations at the island of
Kalymnos, (b) Thymus atticus, whose aerial parts were collected during the flowering
season from native populations growing on mount Parnis and (c) Salvia fruticosa,
whose aerial parts were collected during the flowering season from native populations
in the area of Episkopi at Heraklion, Crete.
The extracts were subjected to a series of chromatographic separations to allow
for the isolation of their secondary metabolites, the chemical structures of which were
elucidated on the basis of the analysis of their spectroscopic data (mainly NMR and
MS). In total, 74 different secondary metabolites were isolated, 60 of which have been
so far identified. Among these, five are new natural products.
In particular, nine secondary metabolites were isolated and identified from the
organic extract of the endemic in East Mediterranean P. lycia, including (i) eight
flavoinoids, one of which is a new natural product, and (ii) one dihydroxybenzoic acid
derivative.
Twenty-eight secondary metabolites were isolated and identified from the
organic extract of T. atticus, including (i) four monoterpenes, which are new natural
products, (ii) five sesquiterpenes, (iii) three diterpenes, (iv) one bis-nor-diterpene, (v)
ten triterpenes, (vi) two steroids, (vii) one flavonoid, (viii) one hydroxycinnamic acid
and (ix) a mixture of fatty acid esters of a phenylethanoid.
Twenty-eight secondary metabolites were isolated and identified from the
organic extract of S. fruticosa, including (i) two monoterpenes, (ii) seven
sesquiterpenes, (iii) thirteen diterpenes, (iv) two nor-diterpenes and (v) four triterpenes.
A number of the isolated secondary metabolites were evaluated for their
antioxidant activity using the DPPH assay.

Science

Phlomis lycia, Thymus atticus, Salvia fruticosa, isolation, Labiatae, secondary metabolites, antioxidant activity

Yes

4

Yes

281

418

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https://pergamos.lib.uoa.gr/uoa/dl/object/2946347