Κατεύθυνση Έρευνα στην Γυναικεία Αναπαραγωγή
Library of the School of Health Sciences

2021-07-23

2021

Zymperdikas Christos

Γουλής Δημήτριος, Καθηγητής, Ιατρική Σχολή, ΑΠΘ
Γκριμπίζης Γρηγόριος, Καθηγητής, Ιατρική Σχολή, ΑΠΘ
Μαστοράκος Γεώργιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Επίδραση του σακχαρώδη διαβήτη τύπου 1 ή 2 σε υπογόνιμες γυναίκες που υποβάλλονται σε τεχνικές υποβοηθούμενης αναπαραγωγής: Συστηματική ανασκόπηση

English

Assisted reproduction technologies outcomes in women with infertility and diabetes mellitus type 1 or 2: Systematic review

BACKGROUND
Objective: To assess pregnancy, maternal and neonatal outcomes in women with or without diabetes mellitus (DM) undergoing assisted reproduction technologies (ART).

METHODS
Eligibility criteria: Prospective or retrospective controlled trials reporting on women with or without DM undergoing ART treatment.
Information sources: Twelve electronic databases were systematically searched up to December 2019, complemented by additional manual searches.
Risk of bias: The risk of bias assessment was performed by the Cochrane’s Risk Of Bias In Non-randomized Studies - of Interventions (ROBINS-I) tool.
Synthesis of results: Each primary outcome was extracted and pooled as mother- and infant-related. In the case of a sufficient number of studies, risk ratios and the corresponding 95% confidence intervals were calculated and implemented in a random-effect model to account for presumed existing heterogeneity.

RESULTS
Included studies: Two studies were included in the present systematic review, reporting on both mother and neonate-related parameters after ART treatment.
Description of the effects: Preterm birth, placenta previa and excessive bleeding during pregnancy were detected more often in pregnancies with DM conceived by ART-protocols than pregnancies without DM. On the other hand, there is no difference in the possibility of placenta abruptio between these two groups. Regarding the neonatal outcomes, large-for-gestational-age (LGA) embryos and neonatal intensive care unit (NICU) admission were more commonly reported for women with DM. However, marginal results were found regarding neonatal or infant mortality.

DISCUSSION
Strengths and limitations: The present review was conducted and reported in accordance with existing guidelines and the respective methodology was strictly followed in every stage of the study. However, only two studies were included, which were found to present methodological limitations and reported only a few maternal and neonatal outcomes.
Interpretation: Based on the current literature, DM in pregnancies conceived by ART is associated with specific maternal and neonatal complications.

OTHER
Funding: No funding
Registration: Registered in PROSPERO (Registration number: 143187)

Health Sciences

Diabetes mellitus, Pregnancy outcome, Neonatal complications, ART, Assisted reproductive techniques

No

0

Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/2957789/file.pdf

https://pergamos.lib.uoa.gr/uoa/dl/object/2957789