Faculty of Medicine
Library of the School of Health Sciences

2021-08-22

2021

Dimosthenopoulos Charilaos

Νικόλαος Τεντολούρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αθανάσιος Πρωτογέρου, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Μακρυλάκης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αλέξανδρος Κόκκινος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αθανάσιος Ράπτης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Βαΐα Λαμπαδιάρη, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αναστασία Θανοπούλου, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ

Η επίδραση τριών διαφορετικών τύπων διατροφής στη γλυκαιμική ρύθμιση των ασθενών με διαβήτη τύπου 1 υπό εντατικοποιημένη ινσουλινοθεραπεία και παρακολούθηση με συσκευή συνεχούς καταγραφής γλυκόζης (ΣΣΚΓ)

Greek

The effect of three different diets on the glycemic control of patients with type 1 diabetes on intensive insulin therapy and monitoring with the use of continuous glucose monitoring device (CSM)

Aims: To compare the effects of three differentbut isocaloric dietary patterns (high-protein/low-carbohydrate [HPD] with 20% calories as carbohydrates, Mediterranean/low glycemic index[MED] with 40% carbohydrates and reference diet with 50% carbohydrates [REF]) in patients with type 1 diabetes (T1D).
Materials and methods: In a randomized crossover study,15 patients with T1D were assigned to the three dietary patterns for three separate weeks, with 7-day washout periods in between. Continuous glucose monitoring (CGM) was applied during the intervention periods. The primary outcome was glycemic control, as measured by the percentage of time patients spent within the euglycemic range (TIR70-140mg/dl). Other key glycemic metrics were also investigated as secondary outcomes.
Results: TIR70-140was statistically different (p=0.049) between the three diets, with patients exhibiting higher TIR during the HPD (54.87 ±14.11%) as compared to the REF (48.33 ± 13.72%) and MED (50.53 ± 12.81%). The difference between HPD and REF was statistically significant at the 0.05 level (p=0.020) but not after applying the Bonferroni correction. The HPD diet performed significantly better than the REF diet in terms of glycemic variability (coefficient of variation: 36.18% vs. 41.48% respectively, p=0.009) and time spent in the hypoglycemic range (TBR<70mg/dl: 8.93±7.64%vs. 14.27±10.57% respectively, p=0.007), whereas no statistically significant differences were observed between the MED and the other two diets.
Conclusions: Compared to a REF and a MED diet, a HPD plan may have a positive impact on glycemic control in patients with T1D. During the HPD, patients spent a shorter time in hypoglycemia and exhibited lower glycemic variability.

Health Sciences

High protein diet, Low carbohydrate, Type 1 diabetes, Continuous glucose monitoring

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https://pergamos.lib.uoa.gr/uoa/dl/object/2959606