Unit:
Κατεύθυνση Μεταβολικά Νοσήματα των ΟστώνLibrary of the School of Health Sciences
Author:
Zogakis Panteleimon
Supervisors info:
Γεώργιος Λυρίτης, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χρήστος Ζαφείρης, Διδάκτωρ, Ιατρική Σχολή, ΕΚΠΑ
Ισμήνη - Νίκη Δοντά, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Το οστικό τσιμέντο ως μεταφορέας ουσιών και φαρμάκων
Translated title:
The role of bone cement as a drug carrier
Summary:
The aim of the present review was to focus on bone cement, a well reputated biomaterial in orthopedic surgery and its role as a drug carrier in order to obtain an enhanced local therapeutic result.
A thorough article research was performed using electronic databases PubMed, Google Scholar and Cochrane library. Antibiotics represent the prevailing therapeutic category to have been studied after mixture with bone cement. Since the method’s first steps in the 1970s’, it remains a “gold standard” in the prevention and treatment of various cases of bone infection. Several issues, like the mixture’s indications or antibiotic dosage, have already been settled while there is still debate concerning aspects such as cost-benefit of the method’s universal application.
More recently, research efforts have been initiated regarding the use of bone cement as a scaffold for other therapeutic substances. Bisphosphonates, a well-established antiosteoporotic treatment, seem to achieve, in this way, a substantial local antiosteoclastic effect. In addition, there have been several encouraging data, reported both in vitro and in vivo, supporting the mixture’s antineoplastic effect against several tumor types. Emphasis needs to be given on the discovery of methods to encorporate larger drug amount without altering the cement’s mechanical properties in a non-acceptable way. Last but not least, there are some first positive results concerning the use of cement as a means to locally deliver cytostatic substances and locally control several neoplastic bone lesions. This also represents a promising method that needs to be further explored.
In conclusion, bone cement represents a highly efficient drug carrier, with some already established applications and with large potential for future investigation.
Main subject category:
Health Sciences
Keywords:
Bone cement, Antibiotics, Bisphosphonates, Cytostatic, Bone infection, Osteoporosis, Osteolysis, Bone metastasis
Number of references:
208
