Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Chalioti Varvara-Maria
Dissertation committee:
Παρασκευή Ρούσσου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Δέσποινα Περρέα, Ομότιμη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Τούτουζας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Νικητέας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Κόντζογλου, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεράσιμος Τσουρούφλης, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Στυλιανός Κύκαλος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Νέοι παράγοντες οξειδωτικού στρες εκτίμησης της εξέλιξης του εμφράγματος του μυοκαρδίου
Translated title:
New oxidative stress factors to assess the development of myocardial infarction
Summary:
Cardiovascular disease is the most common cause of morbidity and mortality in the general population and in a fairly large percentage is due to atherosclerosis of blood vessels. The purpose of this dissertation is to study two specific indicators: a) Asymmetric Dimethylarginine (ADMA, AsymmetricDimethylarginine) and b) Symmetric Dimethylarginine (SDMA, Symmetric Dimethylarginine) and their association with the occurrence of myocardial infarction. According to international literature (5-8), particularly elevated levels of these markers have been observed in patients with acute myocardial infarction and there seems to be a direct correlation of these markers with the prognosis and progression of myocardial infarction. The analysis of the samples to be tested will correlate the levels of these two indicators with socio-demographic and somatometric characteristics of patients which may affect the development of myocardial infarction.
A total of 66 patients (18 women, 48 men) were studied in whom the concentrations of the following indicators were measured: ADMA, SDMA, CRP (c- reactive protein), Troponin T, on the 1st day of their hospital admission and on the 3rd day of their hospitalization. to the hospital, where they were transported on suspicion of acute myocardial infarction. Furthemore, with the written consent of the patients, a questionnaire was completed regarding the socio-demographic, somatometric characteristics and lifestyle habits of the specific patients. Statistical analysis was performed using the SPSS 23.0 tool.
According to the results of this study, ADMA concentrations on the 1st day of hospitalization: a) showed a positive correlation with patients' nighttime sleep patterns (+0.497, p <0.001), b) showed a positive correlation with the frequency with which they ate out of the house or ordered food from outside, c) showed a negative correlation regarding the recorded physical patient status (-0.304, p = 0.013), d) a personal medical history of hypertension in patients reported a higher concentration of ADMA on the first day of hospitalization (1,818 vs 1,568, p = 0.042).
Also , SDMA concentrations on the 1st day of hospitalization:a) in terms of age showed a positive correlation (+0.320, p = 0.009), b) the daily number of hours of sleep in a range of 5-8 hours, showed a negative correlation regarding the reduction of SDMA between 1st to 3rd day.
It should also be noted that the concentrations of all four biomarkers measured ADMA, SDMA, CRP and Troponin T, were mostly reduced on the 3rd day of hospitalization of patients (p <0.001). In summary, it can be seen from the above that some factors such as patients' eating habits, BMI, fitness and nighttime sleep affect ADMA and SDMA levels and therefore modification of these factors could potentially affect the progression of myocardial infarction
Main subject category:
Health Sciences
Keywords:
Symmetric dimethylarginine, Asymmetric dimethylarginine, Myocardial infarction, Oxidative stress, Atheromatosis
