Unit:
Κατεύθυνση Κλινικές Μελέτες: Σχεδιασμός και ΕκτέλεσηLibrary of the School of Health Sciences
Supervisors info:
Τρουγκάκος Ιωάννης , Καθηγητής, Τμήμα Βιολογίας , ΕΚΠΑ
Τσιτσιλώνη Ουρανία, MD,PhD, Τμήμα Βιολογίας, ΕΚΠΑ
Τέρπος Ευάγγελος, Καθηγητής, Ιατρική Σχολή , ΕΚΠΑ
Original Title:
Κλινικές δοκιμές γενετικών θεραπειών με αντιπληροφοριακό RNA και φορείς DNA
Translated title:
Clinical trials of genetics therapies with anti-sense RNA and DNA carry genes
Summary:
Genetic diseases threaten human health and have become increasingly common in the general population in recent years.
Today, gene therapies such as siRNA, shRNA, antisense RNA oligonucleotides, but also genetic carriers, have shown good prospects for their application in clinical practice.Recent developments regarding the chemical transformations of anti-information nucleotides, as well as the development of DNA transport systems (vectors) in order to prevent the breakdown of gene therapy drugs in the body, are of particular importance in the development of gene therapies and their application with greater frequency in clinical practice.In the present study, a systematic review of the literature is performed in order to present the latest developments in relation to clinical trials of genetic therapies with antisense RNA and DNA vectors.
Main subject category:
Health Sciences
Keywords:
Gene therapy drugs, Anti-information RNA, DNA vectors, Genetic diseases, Anti-information oligonucleotides, Anti-information Gene therapydrugs,
Number of references:
150
