Unit:
Κατεύθυνση Αναπαραγωγική-Αναγεννητική ΙατρικήLibrary of the School of Health Sciences
Author:
Cherouveim Panagiotis
Supervisors info:
Μαυρογιάννη Δέσποινα, ΕΔΙΠ, Ιατρική Σχολή, ΕΚΠΑ
Δρακάκης Πέτρος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σταύρος Σοφοκλής, Ακ. Υπότροφος, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Μελέτη του πολυμορφισμού rs4977574 του γονιδίου ANRIL σε γυναίκες με επανειλημμένες απώλειες κύησης
Translated title:
ANRIL rs4977574 polymorphism in women with recurrent pregnancy loss
Summary:
There are many risk factors for recurrent pregnancy loss (RPL). They range from anatomical abnormalities, chromosomal abnormalities, endocrinological dysfunction, thrombophilias, and idiopathic causes. Among them, thromboses/thrombophilias, either inherited or acquired play a major role in RPL development, which is also a common contributing factor to cardiovascular disease. ANRIL gene has attracted increasing attention recently because of its association with cardiovascular disease. However, the potential association of ANRIL with RPL, if any, remains to be established. Thus, the present case-control study involved women with RPL and women following livebirth from a university hospital to investigate this potential correlation. Peripheral blood samples were collected from 56 women with RPL (RPL group) and 69 women following livebirth (Control group). Their DNA was extracted from peripheral blood and polymorphism of interest was enhanced with PCR. RPL group was further stratified according to number of pregnancy losses. OR for the allele A between two and three pregnancy losses was adjusted for maternal age and BMI. Overall, study results suggest different prevalence of ANRIL rs4977574 polymorphism depending on the presence of RPL, while an association with number of RPL cannot be excluded. Consequently, ANRIL gene polymorphism might have a role in the development of RPL. Providing additional evidence for the shared pathophysiological mechanisms hypothesis between cardiovascular diseases and RPL. Further research is required to confirm or reject this correlation and shed light on the underlying mechanism, if one exists.
Main subject category:
Health Sciences
Keywords:
ANRIL, Polymorphism, Recurrent pregnancy loss, Gene, Pregnancy loss
Number of references:
189
