Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Chasikidis Christos
Dissertation committee:
Τούσουλης Δημήτριος, Καθηγητής , Ιατρική Σχολή, ΕΚΠΑ
Τσιούφης Κωνσταντίνος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σιάσος Γεράσιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αγγέλη Κωνσταντίνα Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Παπαϊωάννου Θεόδωρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γκατζούλης Κωνσταντίνος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σταματελόπουλος Κίμων Αν. Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Μελέτη συσχέτισης της λειτουργικότητας των αρτηριών με κλινικούς και υπερηχοκαρδιογραφικούς δείκτες σε ασθενείς με καρδιακή ανεπάρκεια
Translated title:
Association between arterial function and clinical – echocardiographic findings in patients with Heart Failure
Summary:
“Association between arterial function and clinical – echocardiographic findings in patients with Heart Failure”
Arterial stiffness, as a result of atherosclerosis, has been correlated with increased cardiovascular events in general population and patients with comorbidities.
Based on pathophysiology, arterial stiffness has negative effects on afterload and therefore LV function. However, there is no robust data regarding its role in the development and prognosis of Heart Failure (HF).
Aim: Relationship between aortic pulse wave velocity (PWV), as a marker of arterial stiffness and echocardiographic findings in patients with Heart Failure.
Methods: The study population consists of residents of Corinthia prefecture, who are above 40 years old and consented to undergo clinical examination, laboratory tests and a transthoracic echocardiogram. We then measured echocardiographic parameters, such as Left Ventricular Systolic Function (LVEF), Pulmonary Artery Systolic Pressures (PASP) and Left Ventricular filling pressures. Arterial stiffness was assessed by the non-invasive method of SphygmoCor. The diagnosis of heart failure was made based on clinical signs and symptoms, imaging and laboratory findings, in line with the recent guidelines. In the statistical analysis we only included patients with LVEF < 50%. Statistical analysis was performed using the SPSS statistical package.
Results: 103 patients with heart failure were included in the statistical analysis (5% of the initial study population). We compared 2 groups with similar characteristics; with and without heart failure. There was no statistically significant difference in PWV vales between the 2 groups. However, patients with heart failure and PASP≥40mmHg had statistically significant higher PWV values than patients with heart failure and PASP<40mmHg. Moreover, patients with heart failure and increased LV filling pressures had statistically significant higher PWV values compared to those with heart failure, but normal filling pressures.
Outcomes: Higher PWV values are related with worse echocardiographic and clinical findings in patients with heart failure, suggesting a correlation between the function of the arterial wall and the LV function.
Main subject category:
Health Sciences
Number of references:
205
