Unit:
Κατεύθυνση Αλγολογία: Αντιμετώπιση του πόνου, διάγνωση και θεραπεία. Φαρμακευτικές, παρεμβατικές και άλλες τεχνικέςLibrary of the School of Health Sciences
Supervisors info:
Σιαφάκα Ιωάννα, Ομότιμος Καθηγήτρια, Τμήμα Ιατρικής ,ΕΚΠΑ
Βαδαλούκα Αθηνά, Αφ. Αναπληρώτρια Καθηγήτρια, Τμήμα Ιατρικής ,ΕΚΠΑ
Παρασκευά Άντεια, Αναπληρώτρια Καθηγήτρια , Τμήμα Ιατρικής ,ΕΚΠΑ
Original Title:
HIV λοίμωξη και χρόνιος πόνος
Translated title:
HIV infection and chronic pain
Summary:
The evolution of treatment regimens for the management of HIV infection have succeeded in changing the infection from an acute and high-intensity disease with high mortality to a chronic controlled infection with a life expectancy very close to normal. However, along-side the general increase in the prevalence of chronic pain in modern society, there is a high incidence of chronic pain in people living with HIV even in those with low viral load and satisfactory levels of CD4+ T cells. It is therefore found that chronic pain is a significant comorbidity for HIV patients, thus resulting in a reduction in the quality of life and high rates of disability, in addition to the difficulties of HIV infection. The onset of chronic pain during HIV infection is mainly caused by agents and components of the virus, in addition to the side effects of the treatment regimens, and is often established with the form of periph-eral neuropathy. As a result, it is of particular importance to find pharmacologic or non-pharmacologic interventions by which chronic pain will be treated and controlled in these patients. This work concludes with a systematic review of the literature to seek relevant therapeutic approaches. The MEDLINE database is searched using an appropriate strategy with keywords and, following the evaluation and selection process, 23 studies – randomized clinical trials – are collected, of which 16 studies trial pharmaceutical substances and 7 studies test non-pharmacologic interventions. Of the pharmaceutical substances, medical cannabis, lamotrigine and recombinant human nerve growth factor(rhNGF) showed a statis-tically significant advantage over placebo, while of non-pharmacological interventions aer-obic – progressive resisted exercises and acupuncture / moxibustion showed a statistically significant efficacy over placebo / sham. In conclusion, the frequency, intensity and there-fore the cost of chronic pain in people living with HIV is highlighted, the shortage of thera-peutic approaches is identified, and it is suggested for the future to further deepen and re-search on this comorbidity in order to identify or even introduce treatments that will stop its prevalence and consequences.
Main subject category:
Health Sciences
Keywords:
HIV infection, Chronic pain, Peripheral neuropathy, Treatment, Analgesia
