Unit:
Κατεύθυνση ΝευροεπιστήμεςLibrary of the School of Science
Supervisors info:
Σιδηροπούλου Κυριακή, Αναπληρώτρια Καθηγήτρια στο Τμήμα Βιολογίας, Πανεπιστήμιο Κρήτης
Σταματάκης Αντώνιος, Αναπληρωτής καθηγητής Βιολογίας-Βιολογίας Συμπεριφοράς, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Original Title:
Sexual dimorphic performance in the temporal order recognition task and enhanced synaptic plasticity in female C57/BL6 mice after working memory training.
Translated title:
Sexual dimorphic performance in the temporal order recognition task and enhanced synaptic plasticity in female c57/bl6 mice after working memory training.
Summary:
Episodic-like memory, which recollects the "what," "where," and "when" components, and working memory, which is ‘‘active and relevant only for a short period of time’’, are two commonly studied memory systems, which have been thoroughly assessed in male subjects. The major aim of this study was to enrich the inadequate literature on the performance of female mice in tasks that assess the “when” ELM component and WM. The first approach was to compare the general prefrontal cortex function and temporal memory capacity of male and female C57/BL6 mice through the analysis of their PFC-regulated habituation and temporal order object recognition task performance, respectively. Males traveled more in the periphery of the box than females, while there were no differences in the TOR performance. Given that only a few studies have ever suggested that long-term synaptic changes could be associated with some aspects of WM, the second objective was to determine how working memory training in the delayed alternation task alters hippocampal fepsp potentiation after LTP induction. Electrophsyiological recordings in a different cohort of female C57/BL6 mice revealed that fepsp potentiation was greater in non-adaptive but longer-lasting in fully-adaptive mice.
Main subject category:
Science
Keywords:
Φemale C57/BL6 mice, PFC-regulated habituation, Locomotion, Temporal order memory, Working memory, LTP
