Unit:
Κατεύθυνση Επιδημιολογία-Μεθοδολογία έρευνας στις βιοϊατρικές επιστήμες, την κλινική πράξη και τη δημόσια υγείαLibrary of the School of Health Sciences
Supervisors info:
Φίλιππος Ορφανός, ΕΔΙΠ, Ιατρική Σχολή, ΕΚΠΑ
Ανδρονίκη Νάσκα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Γεώργιος Μαρίνος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η επίδραση της λήψης συμπληρωμάτων βιταμίνης Ε στην πρόοδο και εξέλιξη της μη-αλκοολικής λιπώδους νόσου του ήπατος: μια συστηματική ανασκόπηση και μετα-ανάλυση
Translated title:
The effect of Vitamin E supplementation in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis
Summary:
Νon‐alcoholic fatty liver disease (NAFLD) has a global prevalence of 30% among adults with rising tendency among children too and is estimated to be the most common cause of end‐stage liver disease in developed countries. Oxidative stress plays a key role during the course of the NAFLD pathogenesis and vitamin E supplementation has shown to have beneficial effects possibly due to its antioxidative properties. The aim of the present systematic review and meta‐analysis is to investigate the effects of vitamin E supplementation in biochemical parameters in patients with NAFLD.
We performed a literature search in three major electronic databases (MEDLINE, CENTRAL, and Embase) for all randomized clinical trials that examined the effect of vitamin E versus placebo or lifestyle modification (dietary modification with or without encouragement for exercise) in patients with NAFLD, published until June 2022. Changes in serum aminotransferases were considered as the outcomes of interest while the quality of evidence was assessed through risk of bias according to the Cochrane risk of bias tool.
A total of 763 patients from 12 randomized clinical trials were included in the present meta-analysis. Vitamin E did not reduce the values of alanine aminotransferase (ALT) compared with placebo or lifestyle modification but it effectively reduced aspartate aminotransferase (AST) serum values. ALT showed a significant reduction in studies that used vitamin E alone and placebo as a comparator, as well. Additionally, the analysis of Asian patients indicated greater and significant reductions in serum aminotransferases compared to non-Asian studies.
We concluded that vitamin E can improve serum aminotransferases in specific groups of NAFLD patients. Serum aminotransferases are among the commonest means of follow-up of these patients and our results indicate that vitamin E can be considered as a treatment option although further investigations are needed.
Main subject category:
Health Sciences
Keywords:
Non-alcoholic fatty liver disease, NAFLD, Non-alcoholic steatohepatitis, NASH, Aminotransferases, Alanine transaminase, ALT, Aspartate transaminase, AST, Vitamin E, Tocopherol, Tocotrienol
