Unit:
Κατεύθυνση Κλινικές Μελέτες: Σχεδιασμός και ΕκτέλεσηLibrary of the School of Health Sciences
Author:
Moschofidou Maria-Paraskevi
Supervisors info:
Σεργεντάνης Ν. Θεόδωρος, Επίκουρος Καθηγητής, Τμήμα Πολιτικών Δημόσιας Υγείας, ΠΑΔΑ, Επιβλέπων
Φωτίου Δέσποινα, Ακαδημαϊκός Συνεργάτης, Ιατρική Σχολή, ΕΚΠΑ
Ψαλτοπούλου Θεοδώρα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Vitamin D3 status and COVID-19: a systematic review of meta-analyses
Translated title:
Vitamin D3 status and COVID-19: a systematic review of meta-analyses
Summary:
Aim: Accumulating body of evidence suggests a role of vitamin D in the course of coronavirus disease 2019 (COVID-19). However, inconsistency still exists across studies. The primary aim of this systematic review is to analyze the evidence presented in meta-analyses regarding the association between 25(OH) D and the SARS-CoV-2 risk or severity, including admission to intensive care unit (ICU) or mortality. Secondary aim was the effect of supplementation on these outcomes.
Methods: A deep search was conducted using PubMed, EMBASE, Scopus, and Cochrane up to 12 February 2022, including meta-analyses on both observational and interventional studies. Results: Twenty-nine meta-analyses met the inclusion criteria. Sixteen out of eighteen meta-analyses that examined the association between vitamin D status assessed by 25-hydroxy-vitamin D [25 (OH) D] concentrations and SARS-CoV-2 severity and found a strong association, one found a moderate link, and one did not find an association. Then, eight out of ten meta-analyses found an association between the Serum concentrations of 25(OH) D and the risk infection of SARS-CoV-2, one found a moderate link, and one did not find any association. Moreover, 11 meta-analyses assessed the effect of vitamin D supplementation on SARS-CoV-2 risk or severity of infection. Eight out of ten meta-analyses identified a positive effect on disease severity, and three out of six with risk of infection.
Conclusions: The meta-analyses show that VDD is associated with greater severity and risk of SARS-CoV-2infection compared with sufficient vitamin D status.Vitamin D supplementation may reduce the risk of SARS-CoV-2 hospitalization, ICU admission, mortality, and the risk of infection.
Main subject category:
Health Sciences
Keywords:
Vitamin D, 25 (OH) Deficiency/inficeciency, SARS-CoV-2 Severity, Risk of infection, Supplementations, Meta-analyses
