Unit:
Κατεύθυνση Θρόμβωση-Αιμορραγία-Ιατρική των μεταγγίσεωνLibrary of the School of Health Sciences
Author:
Dimitraki Evangelia-Kyriaki
Supervisors info:
Κοκόρη Στυλιανή, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Βαλσάμη Σερένα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, Ε.Κ.Π.Α.
Γαβριηλάκη Ελένη, Επιμελήτρια Β', Ιατρική Σχολή, Ε.Κ.Π.Α.
Original Title:
Ο ρόλος των αντιφωσφολιπιδικών αντισωμάτων σε ασθενείς με λοίμωξη από τον ιό SARS-CoV-2 και η πιθανή συμμετοχή τους στην παθογένεση θρόμβωσης
Translated title:
The role of antiphospholipid antibodies in patients with SARS-CoV-2 infection and their possible involvement in the pathogenesis of thrombosis
Summary:
COVID-19 clinical features include a hypercoagulable state that resembles the antiphospholipid syndrome (APS), a disease characterized by thrombosis and presence of antiphospholipid antibodies (aPL-Abs-including LA). The relationship between aPL-Abs presence and the appearance of thrombi as well as the transience or permanence of aPL-Abs in COVID-19 patients is not sufficiently clear. This could be influenced by the fact that most of the studies carried out were conducted on small populations enriched with elderly patients in which aPL-Abs was measured only at a single point and they were performed with non-standardized assays. The few studies that confirmed aPL-Abs in a second measurement showed that aPL-Abs levels hardly changed, with the exception of the lupus anticoagulant that commonly reduced. COVID-19 coagulopathy is an aPL-Abs independent phenomenon closely associated with the onset of the disease. Thrombosis occurs later in patients with aPL-Abs presence, which is likely an additional prothrombotic factor. B2-glycoprotein deficiency (main aPL antigen caused both by low production and consumption) is very common during the SARS-CoV2 infection and has been associated with a greater predisposition to COVID-19 complications. This could be a new prothrombotic mechanism that may be caused by the blockage of its physiological functions, the anticoagulant state being the most important. In this project, we cite a bibliographical review with the most recent studies concerning the role of aPL-Abs in COVID-19 infection and their involvement in the accompanying thrombotic events of the disease, alongside with reports on a series of 50 patients with COVID-19 infection from ATTIKON General Hospital of Athens, concerning the aPL-Abs occurrence.
Main subject category:
Health Sciences
Keywords:
COVID-19, Thrombosis, Antiphospholipid syndrome, Antiphospholipid antibodies, Autoimmunity
Number of references:
199
