Unit:
Κατεύθυνση Παιδιατρική ΛοιμωξιολογίαLibrary of the School of Health Sciences
Author:
Kotzamani Marina-Triantafyllia
Supervisors info:
Ελπίδα Χατζηαγόρου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΑΠΘ
Μαρίζα Τσολιά, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αλεξάνδρα Σολδάτου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η επίδραση των μικροβιακών αποικισμών στην αναπνευστική λειτουργία παιδιών και νεαρών ενηλίκων με κυστική ίνωση
Translated title:
Impact of microbial colonization in lung function of children and young adults with cystic fibrosis
Summary:
Background: Lung disease is the leading cause of morbidity and mortality in patients with Cystic fibrosis (CF). Due to the frequent use of antibiotics emerging pathogens are colonizing the respiratory system of the patients. The clinical relevance of these colonizations remains undetermined.
Method: We conducted a retrospective study to investigate the association between lung function and the different species of bacteria or fungi colonizing patients with Cystic Fibrosis. Data were retrieved from medical files of patients that visited the CF Center on an outpatient basis over the years 2017-2021. Spirometry was performed 3 -4 times yearly, while multiple breath washout test (MBW) at least once a year. A cough swab or sputum specimen was collected 3-4 times yearly.
Results: We evaluated 107 patients with a mean age of 12.1 years at first visit. Lung Clearance Index (LCI) and Forced Expiratory Volume in 1 second (ppFEV1) were the main outcomes. The most common colonization patterns identified were transient Non Multidrug Resistant Pseudomonas aeruginosa (N-MDR-PA), transient MSSA and transient Stenotrophomonas Maltophilia. Chronic MDR-PA, transient MRSA and chronic Mycobacterium abscessus colonization were associated with a significant ppFEV1 decrease (Coefficient β (95% CI) = -14.54 (-26.83, -2.25); -10.60 (-19.00, -2.19) and -24.78 (-46.96, -2.59), respectively, (p<0.05)). No significant association was found between colonizations and LCI.
Conclusions: Our results confirm recently published data and provide new insights into bacterial colonisation as key factors for the assessment of lung function decline in CF patients. The relatively small population of the study posed a limitation. Further investigation and larger cohorts are required.
Main subject category:
Health Sciences
Keywords:
Cystic fibrosis, CF, FEV1. LCI, Colonization, Lung function
Number of references:
211
