Unit:
Library of the School of Health SciencesΠΜΣ Μονάδες Εντατικής Θεραπείας και Καρδιολογική Νοσηλευτική
Supervisors info:
Κυρίτση Ελένη, Ομότιμος Καθηγήτρια, Τμήμα Νοσηλευτικής, ΠΑΔΑ
Τούσουλης Δημήτριος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Τούτουζας Κωνσταντίνος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Σύγκριση τιμών τροπονίνης σε ασθενείς με οξύ στεφανιαίο σύνδρομο
Translated title:
Comparison of troponin values in patients with acute coronary syndrome
Summary:
Introduction: High-sensitivity troponin is the preferred serological test for the evaluation of patients with suspected acute coronary syndrome. Non-ST-elevation myocardial infarction (NON-STEMI), ST-elevation myocardial infarction (STEMI), and unstable angina are the three traditional types of acute coronary syndrome(ACS).
Purpose: The purpose of this study was to compare the troponin levels of the first two 24 hours of hospitalization in relation to the final outcome, as well as with demographic and clinical characteristics of patients with ACS
Methodology: The sample of the study consisted of 84 patients, who were hospitalized in the Heart Care Unit or in the Cardiology Clinic at G.N.A "IPPOKRATEIO" with acute coronary syndrome from 2020-2022. Data were recorded from the patients' files, from their history, laboratory and imaging tests. Patients with acute stroke were excluded from the study.
Results: Of the 84 patients (of which 84.5% were men, with a mean age of 63.5±26.7 years, with a mean hospitalization in the Heart Care Unit of 4.06±1.8 days) in 50 % had a final diagnosis of STEMI, 40.5% NON-STEMI, and 9.5% a diagnosis of unstable angina. 90.5% of the sample underwent angioplasty and 9.5% were referred for coronary artery bypass grafting, while a total of three patients died. No statistically significant differences were found in troponin levels on admission, 3 to 6 hours after admission, >6 hours and the next day in relation to sex, age group, body mass index (BMI), smoking and the comorbidities (p>0.05). It was found that patients who underwent therapeutic intervention with angioplasty had lower troponin values at the 3rd and 4th measurement (p=0.009 and p=0.008 respectively), while patients referred for BY PASS had higher troponin values at the 3rd and 4th measurement (p=0.011 and p=0.010 respectively). Regarding final diagnosis, STEMI patients had higher troponin values at the 2nd and 3rd measurement (p<0.001 and p=0.005 respectively) compared to NON-STEMI patients. Also, patients who died had higher troponin values in all measurements, which show a continuously increasing trend, with a statistically significant difference in next-day troponin levels (p<0.001).
Conclusions: High-sensitivity troponin is a safe biomarker for the diagnosis of acute coronary syndromes while taking into account the patient's clinical picture. It is also a reliable indicator of monitoring patients for possible recurrence of infarction and/or the need for further intervention. Finally, high-sensitivity troponin is used as a prognostic factor for the final outcome of acute coronary syndromes.
Main subject category:
Health Sciences
Keywords:
High-sensitivity troponin, Acute coronary syndromes, STEMI infarction, NON STEMI infarction
Number of references:
148
File:
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Manioudaki_Sofia_MSc.pdf
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File access is restricted only to the intranet of UoA.
