Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Dissertation committee:
Θεοδοσιάδης Παναγιώτης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Βρυώνη Γεωργία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Λαμπαδιάρη Βάια, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ράπτης Αθανάσιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κρούπης Χρήστος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χατζηράλλη Ειρήνη, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Σεργεντάνης Θεόδωρος, Επίκουρος Καθηγητής, Τμήμα Πολιτικών Δημόσιας Υγείας, ΠΑΔΑ
Original Title:
Αξιολόγηση της συσχέτισης εργαστηριακών και ανατομικών βιοδεικτών σε ασθενείς με διαβητική αμφιβληστροειδοπάθεια
Translated title:
Correlation between laboratory biomarkers and imaging morphological findings in patients with diabetic retinopathy
Summary:
Purpose: To investigate the potential association between peripheral blood biomarkers and morphological characteristics of retinal imaging in patients with diabetic macular edema (DME), as well the investigation of potential laboratory and imaging biomarkers as treatment response predictors to intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents in patients with diabetic macular edema (DME).
Methods: The study included 36 treatment naïve patients with DME, who were treated with intravitreal anti-VEGF agents and followed-up for 12 months. At baseline, all participants underwent best-corrected visual acuity (BCVA) measurement, dilated fundoscopy, optical coherence tomography, color fundus photography and fluorescein angiography, while full blood count and biochemical analysis of various parameters was also performed. Potential associations between laboratory/imaging biomarkers and treatment response were assessed. At month 12, treatment response was examined and classified as “favorable” or “non-response.
Results: Eyes with central subfield thickness greater than 405 μm presented significantly higher neutrophils/lymphocytes (p=0.043) and higher lipoprotein (a) compared to eyes with CST<405 μm (p=0.003). Presence of hyperreflective foci on OCT was associated with significantly higher white blood cell count (p=0.028). Ellipsoid zone disruption was associated with significantly lower hematocrit (p=0.012), hemoglobin (p=0.009) and red blood cells count (p=0.026), as well as with higher lipoprotein (a) (p=0.015). Macular ischemia on FFA was associated with significantly higher monocytes (p=0.027) and monocytes/HDL (p=0.019). No significant associations were found between laboratory parameters and subretinal fluid, intraretinal fluid, exudates, cysts, disorganization of inner retinal layers, epiretinal membrane and external limiting membrane condition. Furthermore, at the multivariate analysis, CST was found to be independent predictor of treatment response, while EZ, ELM and ERM were found to predict “favorable” treatment response.
Conclusion: Specific imaging morphological characteristics were found to be associated with laboratory parameters in patients with DME. Also, intact EZ and ELM, absence of ERM and CST≤405 μm at baseline can predict favorable treatment response in patients with treatment naïve DME, while no correlation with baseline laboratory parameters was found.
Main subject category:
Health Sciences
Keywords:
Diabetic macular edema, Morphological findings and laboratory biomarkers, Optical coherence tomography, Anti-VEGF, Treatment
Number of references:
106
File:
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Dimitriou_Eleni_PhD.pdf.pdf
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