Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Gkavogiannakis Nikolaos
Dissertation committee:
Γεράσιμος Φιλιππάτος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Λουκιανός Ραλλίδης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ευστάθιος Ηλιοδρομίτης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σωτήριος Τσιόδρας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Ρίζος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χρήστος Κρούπης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Τούμπουλης, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Συσχέτιση των καρδιακών δεικτών του υπερηχοκαρδιογραφήματος με τους διαλυτούς υποδοχείς των προοδευτικά μη-ενζυματικώς γλυκοζυλιωμένων τελικών προϊόντων (soluble receptor for advanced glycation end products_sRAGE) σε ασθενείς με φλεγμονώδη νόσο του αναπνευστικού
Translated title:
Correlation of echocardiographic cardiac markers with soluble receptor for advanced glycation end products (sRAGE) in patients with inflammatory respiratory disease
Summary:
Background and aims: Asthma is a heterogeneous disease, characterized by chronic inflammation and oxidative stress of the airways. Several inflammatory pathways including activation of the receptor for advanced glycation end products (RAGE) have been described in the course of the disease. DJ-1 is a redox-sensitive protein with multifaceted roles in mast cell homeostasis and an emerging role in the pathogenesis of asthma. Moreover, cardiac function abnormalities have been described via echocardiography in patients with asthma. The main aim of this study was to investigate the plasma levels of IL-1β, IL-6, RAGE, its ligands and DJ-1 in asthmatic patients pre- and post-treatment along with echocardiographic indices of cardiovascular function.
Methods and Results: The study population was divided into two groups. Group A included 13 patients with newly diagnosed bronchial asthma who were free of treatment for at least two weeks and Group B included 12 patients without asthma. An echocardiography examination was performed on all patients. The plasma levels of RAGE, its ligands (AGEs, S100A12, S100B, S100A8/A9), the interleukins (IL-6, IL-1β) and DJ-1 were measured. No differences were noted among the two groups for baseline characteristics and echocardiographic indices of cardiac function. In Group A, 31% suffered from mild asthma, 54% from moderate asthma and 15% from severe asthma. Plasma levels of IL-6, AGEs and AGE/RAGE ratio were increased and those of S100A12 and DJ-1 were decreased in asthmatics. Furthermore, pharmacotherapy with ICS/LABA decreased IL-6, and AGEs, and increased DJ-1 with a corresponding clinical response and positive correlations between IL6, S100A8/A9, sRAGE and of DJ1 with spirometry parameters.
Conclusion: In search of novel approaches in diagnosing and treating patients with asthma without organic cardiovascular disease, S100A12, ratio AGE/sRAGE, and DJ-1 in addition to IL-6 may prove to be useful tools. Further studies are needed to elucidate their role in asthma and to investigate whether modifying circulating levels of pro-inflammatory/antioxidant proteins can modify disease severity.
Main subject category:
Health Sciences
Keywords:
Asthma, Echocardiography, Inflammation, RAGE, Oxidative stress
Number of references:
380
