Unit:
Κατεύθυνση Γενική και Εξειδικευμένη Παιδιατρική: Κλινική Πράξη και ΈρευναLibrary of the School of Health Sciences
Author:
Andrianopoulou Evangelia-Thedora-Pelagia
Supervisors info:
Αλεβιζόπουλος Γεώργιος, Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Λιάπη Χάρις, Αφυπηρετήσασα Καθηγήτρια, Τμήμα Ιατρικής, ΕΚΠΑ
Μπριάνα Δέσποινα, Αναπληρώτρια Καθηγήτρια, Τμήμα Ιατρικής, ΕΚΠΑ
Original Title:
Η επίδραση της αντιψυχωτικής αγωγής κατά την διάρκεια της κύησης στην νευροανάπτυξη του παιδιού
Translated title:
The effect of antipsychotic treatment, during the perinatal period, on the neurodevelopment. of children: a systematic review and meta-analysis
Summary:
Introduction: The study aims to investigate the neurodevelopmental effect of antipsychotic drugs in children born to mothers who received, during the perinatal period, typical or atypical antipsychotics.
Methodology: Databases were searched according to inclusion and exclusion criteria. The studies involved mothers with preconception or relapsed mental illness receiving antipsychotic medication during the perinatal period and their children were screened for any neurodevelopmental disorders due to their exposure to antipsychotic medication.
Results: 3 studies were identified in which children were exposed and developed ADHD with a pooled odds ratio of 2.33 (95% CI = 1.69 – 3.20) indicating that children exposed to antipsychotics are 2, 33 times more likely to develop ADHD than unexposed children. This relationship was statistically significant (p<0.001). Regarding Socio-emotional and Mental development, it was found that the pooled odds ratio was 2.33 (95% CI = 1.68 – 3.22) indicating that exposed children were 2.33 times more likely to show delay compared to unexposed children. This relationship was statistically significant (p<0.001). Finally, it was found that children who were exposed and showed a delay in motor development had a pooled odds ratio of 2.93 (95% CI = 1.86 – 4.61). Thus, children exposed to antipsychotics were 2.93 times more likely to be delayed in motor development than children not exposed. This relationship was statistically significant (p<0.001).
Discussion: Fetal exposure to antipsychotics can cause short-term developmental delays in motor, social-emotional, and adaptive behavior. However, further investigation is needed.
Main subject category:
Health Sciences
Keywords:
Antipsychotic treatment, Pregnancy, Neurodevelopmental disorders
Number of references:
146
