Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Kartsiouni Elpiniki
Dissertation committee:
Κωνσταντίνος Δούρος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ (επιβλέπων)
Βασιλική Παπαευαγγέλου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Στυλιανός Χατζηπαναγιώτου, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δέσποινα Μπριάνα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Σμαραγδή Φεσσάτου, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Λάμπρος Φώτης, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αναστάσιος Ιωαννίδης, Επίκουρος Καθηγητής, Τμήμα Νοσηλευτικής, Πανεπιστήμιο Πελοποννήσου
Original Title:
Μελέτη του είδους των μικροβίων στην εμμένουσα βακτηριακή βρογχίτιδα και τη βρογχεκτασία σε παιδιά που δεν πάσχουν από Κυστική Ίνωση
Translated title:
Study of the microbes in children with protracted bacterial bronchitis or non- cystic fibrosis bronchiectasis
Summary:
Background/Aim: Children with chronic wet cough and without cystic fibrosis (non-CF) may suffer from protracted bacterial bronchitis (PBB), chronic suppurative lung disease (CSLD) or bronchiectasis. Bronchiectasis is a cause of increased morbidity of the respiratory system. Bronchiectasis result in reduced pulmonary function and poor quality of life. Pseudomonas aeruginosa can be one of the offending microbes in these children. The present study aimed to describe the type and the role of microbes in these children and especially the clinical course of children with the above two conditions who were infected with Pseudomonas aeruginosa.
Methods: Data of 54 children with PBB/ CSLD, non- CF bronchiectasis and Pseudomonas aeruginosa isolation were studied, specifically their demographic characteristics, disease history, diagnostic and therapeutic approach and disease outcome at the end of the follow- up period. These children analyzed through a Cox proportional hazard model, with age, presence of bronchiectasis, use of inhaled colistin, azithromycin, inhaled hypertonic saline as the covariates. Disease remission was defined as the absence of daily wet cough for six months along with three negative cultures taken during the last three consecutive follow-up visits.
Results: The 31 children in the study population were boys and 23 were girls, the median age was one year and they had been experiencing a wet cough for about 1.5 years prior to Pseudomonas isolation. Nebulised antibiotics and the presence of bronchiectasis were statistically significant predictors of remission (HR:3.99; 95%CI:1.12-14.14; p= 0.032, and HR:0.24; 95%CI:0.08-0.71; p= 0.010). In contrast, there was no association between age, azithromycin use, hypertonic solution inhalation and disease remission.
Conclusion: Pseudomonas aeruginosa is a microbe that often develops in children with chronic endobronchial infection. The rate of disease remission increases with the use of inhaled colistin and decreases when there is established bronchiectasis.
Main subject category:
Health Sciences
Keywords:
Pseudomonas aeruginosa, Bronchiectasis, Children, Chronic suppurative lung disease
Number of references:
172
